Chest
Original ResearchCritical Care MedicineSurvival for Patients With HIV Admitted to the ICU Continues to Improve in the Current Era of Combination Antiretroviral Therapy
Section snippets
Study Design and Subjects
We conducted a retrospective cohort study of all HIV-infected adults who had been admitted to the ICU at SFGH from 2000 through 2004. SFGH is an urban public hospital, with 375 beds and 30 ICU beds. A computerized search of SFGH ICU admissions using the International Classification of Diseases, ninth revision, diagnostic code for HIV (042) identified patients with HIV who had been admitted to the ICU. The University of California, San Francisco, Committee on Human Research approved the study
Results
There were 311 ICU admissions for 281 patients. Twenty-five patients (9%) had more than one ICU admission during the 5-year study period. Because few patients had repeat ICU admissions, each ICU admission that occurred during a subsequent hospitalization was treated as a separate event. The predictors of survival identified from the multivariate analysis were unchanged if these repeat patient admissions were excluded.
Discussion
This study is notable in that it is the sixth in a series of consecutive studies that was started in 1981 to examine the critical care provided to HIV-infected patients at SFGH.2, 9, 12, 13, 17 In addition, our study is among the few studies to examine HIV patients who have been admitted to the ICU since the year 2000, and we have noted several important trends. Our study shows that in the current era of ART respiratory failure remains the most common indication for ICU admission, although the
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The contents of this study are solely the responsibility of the authors and do not necessarily represent the official view of the National Center for Research Resources of the National Institutes of Health. Information on the National Center for Research Resources is available at http://www.ncrr.nih.gov/. Information on Re-engineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp.
This research was funded by NIH grants 1F32HL088990 (J.L.D.), 1R01HL090339 (A.M.), 5K24HL087713 (L.H.), and 1R01HL090335 (L.H.). This project was also supported by grant No. 1 UL1 RR024131–01 from the National Center for Research Resources, a component of the NIH, and by the NIH Roadmap for Medical Research.
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).