Chest
ORIGINAL RESEARCHCOPDDynamic Hyperinflation During Daily Activities: Does COPD Global Initiative for Chronic Obstructive Lung Disease Stage Matter?
Section snippets
Subjects
Thirty-two clinically stable patients with COPD, GOLD stage II (n = 10), III (n = 12), and IV (n = 10), participated in this study. Patients were recruited from our outpatient clinic. Exclusion criteria were long-term oxygen therapy, respiratory insufficiency, asthma, exercise-limiting comorbidity, or an exacerbation within 4 weeks before the study. The study was conducted according to the Declaration of Helsinki and was approved by the medical ethical committee of our hospital. Written
Subjects
Age, gender, and BMI were comparable across the GOLD groups (Table 1). Smoking history was similar between the groups (II, 38 ± 9; III, 34 ± 5; IV, 32 ± 5 pack-years). All but three patients used long-acting bronchodilation. GOLD IV subjects showed significantly lower ICrest and ICrest/TLC ratios than GOLD II and III subjects (Table 1), reflecting more static hyperinflation. According to the MMRC and CCQ scores, patients with more severe disease were more disabled.
ADLs
Activities varied from vacuum
Discussion
We showed in this study for the first time that DH occurred independent of disease severity according to GOLD during real-life ADLs. There was a tendency for less DH in the most severe COPD group. The amount of DH was at least partially determined by the level of static hyperinflation as reflected by ICrest or ICrest/TLC.
With increasing GOLD stage, scores of disability increased, which was reflected by the choice of less heavy tasks (tendency to lower o2), shorter ADL time, and more
Acknowledgments
Author contributions: Dr Hannink: contributed to designing the study, performing all measurements and data analyses, writing the manuscript, and reading and approving the final manuscript.
Dr van Helvoort: contributed to providing guidance for the development of the study design and interpretation of the results, providing comments on the manuscript, and reading and approving the final manuscript.
Dr Dekhuijzen: contributed to providing guidance for the development of the study design, providing
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