Chest
Original ResearchCystic FibrosisPrevalence of Symptoms of Anxiety and Depression in German Patients With Cystic Fibrosis
Section snippets
Procedures
Staff members at 31 German and one Austrian (Innsbruck) CF centers attempted to screen all patients aged 12 years through adulthood. The study protocol was approved by the Ethics Committee at the University Ulm and the local institutional review boards of the participating CF centers. After completion of informed consent/assent, the Hospital Anxiety and Depression Scale (HADS) and the additional questionnaires assessing sociodemographic and medical variables were administered by a staff member
Study Sample
A total of 670 patients with CF (aged 12-64 years, Mean = 23.1 years, 52.7% male) were enrolled, which was approximately 50% of all eligible patients at the participating sites. Table 1 shows the sample characteristics of patients in the study group and the nonparticipants aged 12 and older across all German CF centers (n = 2,629), the latter including also those patients who were not eligible for the study because they were treated in centers that did not participate in TIDES. No significant
Discussion
To our knowledge, this is the first large, representative, multicenter epidemiologic study of anxiety and depression in adolescent and adult patients with CF. The main findings indicated that symptoms of anxiety are more prevalent in adult German patients with CF compared with peers in the community, whereas in no age group were patients more or less depressed than the general population, unless their lung function was severely impaired. Impairments in lung function were associated with more
Acknowledgments
Author contributions: Dr Goldbeck: designed the study in collaboration with The International Depression/anxiety Epidemiological Study (TIDES) group, was responsible for data collection and analyses, and contributed to the writing of the manuscript.
Dr Besier: was responsible for data collection and analyses, and contributed to the writing of the manuscript.
Dr Hinz: contributed data about the control subjects and contributed to the writing of the manuscript.
Dr Singer: contributed data about the
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2016, General Hospital PsychiatryCitation Excerpt :Prior literature addressing this question has produced mixed results. Several national studies of patients with CF reported that those with impaired lung function had more symptoms of depression [9,11,14,20,21]. In contrast, the International TIDES [17] and others [10,13] found minimal associations with lung function.
Funding/Support: The study was supported by a financial grant from the Mukoviszidose Institut gGmbH, the research and development arm of the German Cystic Fibrosis Association Mukoviszidose e.V.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).