Chest
Clinical InvestigationsMiscellaneousA Clinical Study of Idiopathic Eosinophilic Pneumonia
Section snippets
Patients
The subjects included 27 patients with eosinophilic pneumonia whose conditions were diagnosed at the hospital of Hamamatsu University School of Medicine and related hospitals from 1986 to 1992. Pulmonary eosinophilia was detected by bronchoalveolar lavage (BAL) and transbronchial lung biopsy specimen. Biopsy specimens were fixed with 10 percent formalin and stained with hematoxylin-eosin and elastica van Gieson. Microscopic observation revealed occasional intra-alveolar organization as well as
Classification of CEP and AEP
The subjects were classified on the basis of their radiographic findings and clinical course, because CEP and AEP appeared to be best distinguished by these parameters. We found that the classification of CEP and AEP by chest radiographic findings fully coincided with that by the clinical course, and found that the subjects could be divided into 14 with CEP and 13 with AEP.
The typical chest radiographic findings in CEP were dense, multiple foci of consolidation in the peripheral lung fields, as
Discussion
Our observations indicated that IEP is basically divided into two clinical entities, which are CEP and AEP. Most of our data on CEP confirmed the clinical characteristics described previously by several investigators,7,10, 11, 12 except for one minor point. The previous authors have indicated that CEP has an insidious onset with a long interval from the appearance of symptoms to diagnosis, commonly several months.7,10, 11, 12 In contrast, several cases of CEP had acute onset, being diagnosed
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Authors and hospitals participating in this study: Drs. Masatoshi Iwata (Haibara General Hospital); Hiroji Ogawa (Hamana Hospital); Jinichiro Akiyama (Shimada Municipal Hospital); Kazumasa Yasuda (Iwata Municipal Hospital); Yutaka Nakano (Kakegawa Municipal Hospital); Takayoshi Watanabe (Fujinomiya Municipal Hospital); Takeshi Yagi (Hamamatsu University School of Medicine: HUSM); Takafumi Suda (HUSM); Ryoji Tamura (HUSM); Hideki Suganuma (HUSM); Atushi Yoshitomi (HUSM); and Kingo Chida (HUSM)
Revision accepted November 3.