Chest
Original ResearchCritical CareSelf-reported Depressive Symptoms and Memory Complaints in Survivors Five Years After ARDS
Section snippets
Patients
The patients in this study participated in a prospective cohort study of survivors of ARDS enrolled at four University of Toronto-affiliated ICUs between May 1998 and May 2001.4, 8, 9 Eligible patients were aged ≥ 16 years, had a Pao2/Fio2 ratio of ≤ 200 while receiving mechanical ventilation, with a positive end-expiratory pressure of ≥ 5 cm H2O; airspace changes in all four quadrants on chest radiography; and an identifiable risk factor for ARDS. Patients were excluded if they were immobile
Study Participants
We enrolled 109 survivors of ARDS in the cohort, of whom 21 died and 24 were lost to follow-up by the time of the 5-year evaluation9 (Fig 1). Of 74 known survivors at 5 years, 64 patients were evaluated, of whom 46 (71.9%) returned the BDI-II, 47 (73.4%) returned the MAC-S, and 48 (75.0%) returned either one. A median of 41 months (Q1-Q3, 32.5-52 months) separated the two questionnaire administrations.10 Responders were similar to nonresponders (Table 1); they were relatively young (median age,
Discussion
This study included 48 relatively young patients with high illness severity and no documented psychiatric illness who survived ARDS and answered questionnaires assessing depressive symptoms and memory complaints 5 years after ICU discharge. We found that depressive symptoms at 5 years were similar compared with ∼ 2 years after ICU discharge. The SF-36 mental health domains (MH, RE, and MCS), although correlated with BDI-II at 5 years, were completely stable between assessments and may lack
Acknowledgments
Author contributions: Dr Adhikari had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Adhikari: contributed the design of the analyses, interpretation of the data, and drafting and revision of the manuscript.
Dr Tansey: contributed to the data collection and revision of the manuscript.
Dr McAndrews: contributed to the study design and revision of the manuscript.
Ms Matté: contributed to the data collection,
References (55)
- et al.
Long-term neurocognitive function after critical illness
Chest
(2006) - et al.
Self-reported symptoms of depression and memory dysfunction in survivors of ARDS
Chest
(2009) - et al.
Normative data on a self-rating scale for evaluating memory in everyday life
Arch Clin Neuropsychol
(1992) - et al.
Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome
Gen Hosp Psychiatry
(2010) - et al.
The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study
Gen Hosp Psychiatry
(2001) - et al.
Self-report of cognitive abilities in temporal lobe epilepsy: cognitive, psychosocial, and emotional factors
Epilepsy Behav
(2004) - et al.
Affective symptoms and cognitive functions in the acute phase of Graves' thyrotoxicosis
Psychoneuroendocrinology
(2007) - et al.
Perceived and actual memory, concentration, and attention problems after whiplash-associated disorders (grades I and II): prevalence and predictors
Arch Phys Med Rehabil
(2007) - et al.
The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination
Am J Respir Crit Care Med
(1994) - et al.
Incidence and outcomes of acute lung injury
N Engl J Med
(2005)
Has mortality from acute respiratory distress syndrome decreased over time? a systematic review
Am J Respir Crit Care Med
One-year outcomes in survivors of the acute respiratory distress syndrome
N Engl J Med
Quality of life after acute respiratory distress syndrome: a meta-analysis
Intensive Care Med
Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review
Psychosom Med
Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome
Am J Respir Crit Care Med
Functional disability 5 years after acute respiratory distress syndrome
N Engl J Med
A self-rating scale for assessing memory loss
A self-rating scale for evaluating memory in everyday life
Psychol Aging
The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection
Med Care
Psychometric evaluation of the Beck Depression Inventory-II with primary care medical patients
Health Psychol
Factor structure of the Beck Depression Inventory-II in a medical outpatient sample
J Clin Psychol Med Settings
The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs
Med Care
The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups
Med Care
Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the Medical Outcomes Study
Med Care
Canadian normative data for the SF-36 health survey
CMAJ
Quality of life in adult survivors of critical illness: a systematic review of the literature
Intensive Care Med
Cited by (62)
Cognitive impairment in people with previous COVID-19 infection: A scoping review
2022, CortexCitation Excerpt :We cannot a priori exclude psychiatric factors as determinants of the reported cognitive sequelae in post-COVID-19. Also, the limited duration of follow-up in the retrieved studies prevents the definition of the natural history of this disturbance: PTSD may persist up to 12 months from hospital discharge (Parker et al., 2015), and this also includes depression (Jackson et al., 2014), which may be observed in some cases up to 5 years (Adhikari et al., 2011), and anxiety (Hopkins et al., 2010; Mikkelsen et al., 2012; Myhren et al., 2010). Long-term follow-up studies are needed to monitor the eventual evolution pyscho-affective symptoms after a COVID-19 infection.
Post-COVID-19 memory complaints: Prevalence and associated factors
2022, NeurologiaCitation Excerpt :Arentz et al. (2020) found, more than two-thirds of COVID-19 patients admitted to intensive care units required mechanical ventilation, and all of them developed acute respiratory distress syndrome (ARDS) within three days.25 In addition, several studies observing the long-term outcome of patients who have suffered from ARDS have found loss in memory function,26,27 even lasting up to five years.28 As of October 2021, over 234 million people have recovered from COVID-1929; however, various symptoms have been observed to persist even after recovery from this disease.30
Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome
2021, Journal of Critical CareCitation Excerpt :However, for many of the altruistic benefits of research study participation to accrue, for both the patient and future research, participants must be able to recall their participation in a trial. Patients who experience critical illness often report memory deficits of their illness and hospitalization [4,5]. This lack of recall for hospitalization events can persist well beyond discharge [5].
Funding/Support: This work was performed at the University of Toronto and was supported by Physicians' Services Incorporated, Ontario Thoracic Society, and Canadian Intensive Care Foundation. Dr Cheung is supported by a Canadian Institutes of Health Research Senior Investigator Award and the Lillian Love Chair in Women's Health at the University of Toronto and University Health Network.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).