Chest
Clinical Investigations: InfectionLaboratory Abnormalities in Patients With Bacterial Pneumonia
Section snippets
MATERIALS AND METHODS
We reviewed the medical records of 353 consecutive patients admitted to Long Island Jewish Medical Center, New Hyde Park, NY, from January 1, 1993 through December 31, 1993, who had bacterial pneumonia as their discharge diagnosis. Of these, 302 patients had documented evidence of bacterial pneumonia, based on chest radiographic evidence of infiltrate with or without positive sputum culture. All of them had at least one full blood chemistry panel drawn at the time of hospital admission.
RESULTS
The total medical admissions to the Long Island Jewish Medical Center over a 3-month period included 7,994 patients. Of these, 640 had documented hypophosphatemia at admission or some time during their hospital stay (8%). In the control group of 300 patients, 31 had documented hypophosphatemia (10.3%). Among 302 patients with a discharge diagnosis of bacterial pneumonia, 135 patients had documented hypophosphatemia (44.7%) (p<0.0001 compared to all hospitalized patients and control group). The
DISCUSSION
The elderly ambulatory patient who comes to the emergency department with fever is very likely to have a serious pneumonia and in most instances will require hospitalization.21 Even in young, healthy naval personnel, pneumonia has been found to be the major medical cause of lost workdays.22 Although in western countries pneumonia has been replaced by more chronic pulmonary disorders as the chief cause of respiratory death, it still remains a very important cause of mortality in the United
CONCLUSION
We conclude that laboratory abnormalities, especially hypophosphatemia, may be a significant risk factor predicting the severity of the underlying illness in hospitalized patients with bacterial pneumonia.
REFERENCES (32)
- et al.
Symposium on infectious lung diseases: foreword
Med Clin North Am
(1980) Overwhelming pneumonia
Med Clin North Am
(1983)- et al.
Extra charges and prolongation of stay attributable to nosocomial infections: a prospective interhospital comparison
Am J Med
(1981) - et al.
Hypophosphatemia: a complication of 'innocuous dextrose-saline.
Lancet
(1976) Phosphate homeostasis and hypophosphatemia
Am J Med
(1982)- et al.
The effect of voluntary overbreathing on the electrolyte equilibrium of arterial blood in man
J Biol Chem
(1946) - et al.
Role of respiratory assistance devices in endemic nosocomial pneumonia
Am J Med
(1981) - et al.
Nosocomial infections and hospital deaths: a case-control study
Am J Med
(1983) - et al.
Respiratory illness and hypophosphatemia
Chest
(1983) - et al.
Hypophosphatemia in a hospital population
BMJ
(1972)
Serum inorganic phosphate in a geriatric in-patient population
Gerontol Clin
Clinical relationships between serum phosphorus and other blood chemistry values in alcoholics
Arch Intern Med
Hypophosphatemia in hospitalized patients
JAMA
Hypophosphatemia as diagnostic aid to sepsis: study of 141 patients
NY State J Med
The pathophysiology and clinical characteristics of severe hypophosphatemia
Arch Intern Med
Clinical hypophosphatemia
Annu Rev Med
Cited by (49)
Changes in arterial pH do not explain the reductions in ionised calcium observed during COVID-19 infection
2024, Advances in Medical SciencesHematological characteristics of patients with novel coronavirus pneumonia in intensive care unit
2021, International ImmunopharmacologyCitation Excerpt :In terms of blood calcium levels, the two groups showed varying degrees of decreases, with the critical group showing a more obvious decrease. Accompanied by tissue and organ ischemia and hypoxia, severe infection in critical patients could result in changes in cell membrane permeability and a decrease in the activity depending on the adenosine triphosphate function of calcium pumps, eventually leading to accumulation of intracellular calcium and a decrease in blood calcium levels [18]. The reduced blood calcium levels indicated a severe disease and poor prognosis.
Diagnosis and prediction of COVID-19 severity: can biochemical tests and machine learning be used as prognostic indicators?
2021, Computers in Biology and MedicineIs hypophosphataemia an independent predictor of mortality in critically ill patients with bloodstream infection? A multicenter retrospective cohort study
2021, Australian Critical CareCitation Excerpt :We can make the hypothesis that the deaths associated with hypophosphataemia are due more to organ dysfunctions than to sepsis insufficiently controlled by antibiotics. Previous studies have reported an association between hypophosphataemia and the risk of death.1,20,28–32 Shor et al.20 reported significantly higher mortality rates associated with hypophosphataemia in patients with sepsis.
Prevalence and predictive value of hypocalcemia in severe COVID-19 patients
2020, Journal of Infection and Public Health
Reprint requests: Dr. Singhal, Division of Nephrology, Room 228, Long Island Jewish Medical Center, New Hyde Park, NY 11040