Chest
Selected ReportsPulmonary Langerhans’ Cell Histiocytosis: Radiologic Resolution Following Smoking Cessation
Section snippets
Case 1
A 43-year-old woman was admitted to the hospital with a 3-month history of a nocturnal cough associated with intermittent chest tightness. She had been previously well with no history of dust or chemical exposures. She was a smoker, starting at the age of 20 years and averaging 20 cigarettes a day. Physical examination revealed sparse fine late inspiratory crackles at both bases. Breast examination was normal. Routine hematologic studies were normal; there was no peripheral eosinophilia, the
Discussion
The etiology of LCH remains obscure, but the vast majority (up to 97%) of the patients are current smokers or ex-smokers. The course of this disease is variable, ranging from spontaneous remission to progressive disease and death.14 Since remission of the LCH may occur spontaneously even in those who continue to smoke,5 the effect of smoking cessation is often difficult to resolve. We describe two patients in whom there was a close temporal and sustained relationship between smoking cessation
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