Chest
Clinical InvestigationsBrain/Lung InteractionLower Pulmonary Function and Cerebral Subclinical Abnormalities Detected by MRI: The Atherosclerosis Risk in Communities Study
Section snippets
Materials and Methods
The sample for this report consisted of 1,917 individuals who participated in the cerebral MRI study at two study sites of the Atherosclerosis Risk in Communities (ARIC) study. ARIC is a longitudinal study of cardiovascular and pulmonary diseases sponsored by the National Heart, Lung, and Blood Institute. It includes a community surveillance and a cohort component. The ARIC cohort was selected as a probability sample of 15,800 men and women between the ages of 45 and 64 years old at four study
Results
The mean age of participants was 62 years old; 50% were African Americans, and 40% were men. The characteristics of the sample, both overall and stratified by cerebral abnormality and by the lung function, are presented in Table 1. The profile of cardiovascular and cerebrovascular disease risk factors was similar to that of African-American and European-American men and women of similar age in the full ARIC cohort from the two study sites. When stratified by the presence of cerebrovascular
Discussion
Asymptomatic cerebral infarction and WMLs are considered to be sequelae of arteriosclerosis, cerebral hypoperfusion, or ischemia.1234567891011 The prevalence of infarction was 30% in individuals aged ≥ 65 years old examined by the Cardiovascular Health Study6 and about 15% in our sample of men and women aged≥ 55 years old . The prevalence of WMLs was 27 among 100 individuals ages 65 to 85 years old examined by the Rotterdam Study,1187% in the Cardiovascular Health Study cohort,25 and 85% in the
References (28)
- et al.
Cerebral white matter lesions and atherosclerosis in the Rotterdam Study
Lancet
(1993) - et al.
The high incidence of pulmonary function abnormalities in patients with coronary artery disease
Chest
(1974) - et al.
A short questionnaire for the measurement of habitual physical activity in epidemiological studies
Am J Clin Nutr
(1982) - et al.
Pulmonary function and cardiovascular risk factor relationships in black and in white young men and women: the CARDIA Study
Chest
(1991) - et al.
White matter lesions in the elderly [review]
J Neurol Sciences
(1992) - et al.
Neuropsychological correlates of white matter lesions in healthy elderly subjects
Arch Neurol
(1992) - et al.
Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors
Stroke
(1986) - et al.
Leucencephalopathy in normal and pathologic aging: II. MRI of brain lucencies
AJNR Am J Neuroradiol
(1986) - et al.
Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults: the Cardiovascular Health Study; CHS Collaberative Research Group
Stroke
(1997) - et al.
The spectrum of subcortical lesions in MRI, sensitivity and specificity
J Neural Transm
(1991)
Periventricular lesions in the white matter on magnetic resonance imaging in the elderly: a morphometric correlation with arteriolosclerosis and dilated perivascular spaces
Brain
Brain MR: pathologic correlation with gross and histopathology; 2. Hyperintense white matter foci in the elderly
AJR Am J Roentgenol
The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study
Neuroepidemiology
Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study
Neurology
Cited by (64)
Relationship between chronic obstructive pulmonary disease and cognition in an aging population
2022, Journal of Psychosomatic ResearchAssociation between airflow limitation and leukoaraiosis of the brain
2021, Respiratory InvestigationReduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals
2020, NeuroImage: ClinicalCitation Excerpt :CSVD is strongly associated with incident ischemic and hemorrhagic stroke (Debette and Markus, 2010), progressive cognitive dysfunction (Gorelick et al., 2011), and vascular risk factors (Jackson et al., 2010). Previous studies have shown that impaired lung function is associated with increased WMH (Longstreth et al., 1996, Liao et al., 1999, Spilling et al., 2017), but few studies have shown the relationship between other CSVD markers such as lacunes and microbleeds and pulmonary function. Another important biomarker for predicting cognitive impairment in cognitively normal individuals is cortical thickness.
Neurologic Complications of Solid Organ Transplantation
2017, Neurologic ClinicsFrailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
2016, Molecular Aspects of Medicine
Support for this study was provided by National Heart, Lung, and Blood Institute Contracts N01-HC-55018, N01-HC-55019, N01-HC-55021, and N01-HC-35126, and by American Heart Association Scientific Development Award 9730175N.