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Clinical Investigations in Critical CareOutcome in Noninvasively and Invasively Ventilated Hematologic Patients With Acute Respiratory Failure
Section snippets
Study Location and Subjects
We have studied a cohort of 230 consecutive patients with hematologic malignancies or aplastic anemia who were admitted to the medical ICU of the Ghent University Hospital between January 1, 1997, and June 30, 2002. This 14-bed unit admits critically ill patients who are at least 15 years old. Of these 230 patients, 166 (72.2%) received MV. Twenty-six patients received NPPV. Demographic, clinical, laboratory, and physiologic data were recorded retrospectively in 68 patients (within the period
Patients
A total of 166 patients with a hematologic malignancy received MV in our ICU between January 1, 1997, and June 30, 2002. Patient characteristics, as well as the principal reasons for ICU admission are summarized in Table 1. However, it is important to note that most patients had a combination of ICU admission reasons. The Pao2/Fio2 ratio was < 300 in 141 patients (85%) and < 200 in 118 patients (71%). Data on Paco2 and pH were available in 96 patients. In 35 patients (41%), hypercapnia (ie, Paco
Discussion
The in-hospital mortality rate in our population of hematologic patients with ARF was 70.5%. Although we could not compare this mortality rate with earlier data from our institution, this figure is well in accordance with mortality rates for mechanically ventilated cancer patients that have been reported in the literature.14161824 Those studies illustrate that improving survival in critically ill hematologic patients also reflects a modest gain in survival in those patients who develop ARF
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Invasive mechanical ventilation in patients with solid tumor or hematological malignancy
2023, Revue des Maladies RespiratoiresOxygenation strategy during acute respiratory failure in immunocompromised patients
2021, Journal of Intensive MedicineBacteremia in critically ill immunocompromised patients with acute hypoxic respiratory failure: A post-hoc analysis of a prospective multicenter multinational cohort
2021, Journal of Critical CareCitation Excerpt :Although bacteremia has been shown to be an independent risk factor for mortality in unselected patients hospitalized for febrile neutropenia [24], its impact on mortality in critically ill immunocompromised patients has not been clarified. If anything, a reverse association has been reported: a study showed a lower hospital mortality associated with bacteremia in patients with hematological malignancies requiring mechanical ventilation for ARF [14], whereas another study including critically ill patients with hematological malignancies observed no association between bacteremia and outcome [13]. However, these studies only included 29 and 21 patients respectively.
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