Chest
Clinical Investigations: AsthmaEarly Life Risk Factors for Current Wheeze, Asthma, and Bronchial Hyperresponsiveness at 10 Years of Age
Section snippets
Materials and Methods
A whole-population birth cohort was established on the Isle of Wight in 1989 to prospectively study the natural history of childhood wheezing and to identify risk factors for the development of childhood wheezing and asthma. Approval for the study was obtained from the local research ethics committee. Of 1,536 children born between January 1, 1989, and February 28, 1990, informed consent was obtained for 1,456 subjects to be enrolled. Enrollment took place at birth, and information on family
ACKNOWLEDGEMENT
The authors gratefully acknowledge the cooperation of the children and parents who have participated in this study. We also thank Linda Terry, Gail Poulton, Heidi Savory, Tessa Booth, Linda Waterhouse, Andrew Gallini, Cathy Wilby, Rosemary Lisseter, and Roger Twiselton for their considerable assistance with many aspects of the 10-year follow-up of this study. Finally, we would like to highlight the role of the late Dr. David Hide in starting this study.
References (40)
Early sensitisation and development of allergic airways disease: risk factors and predictors
Paediatr Respir Rev
(2003)- et al.
Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
Lancet
(1999) - et al.
Systematic review: exposure to pets and risk of asthma and asthma-like symptoms
J Allergy Clin Immunol
(2001) - et al.
Atopy in children of families with an anthroposophic lifestyle
Lancet
(1999) - et al.
Effect of environmental factors on the development of allergic disorders in infancy
J Allergy Clin Immunol
(1992) - et al.
The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study
J Allergy Clin Immunol
(1998) - et al.
Factors influencing symptom expression in children with bronchial hyper-responsiveness at 10 years
J Allergy Clin Immunol
(2003) - et al.
The development of childhood asthma; lessons from the German Multicentre Allergy Study (MAS)
Paediatr Respir Rev
(2002) - et al.
The relationships between atopy, bronchial hyperresponsiveness, and a family history of asthma: a cross-sectional study of migrant Tokelauan children in New Zealand
Allergy Clin Immunol
(1989) - et al.
Changes in asthma prevalence: two surveys 15 years apart
Arch Dis Child
(1989)
Has the prevalence of asthma increased in children? Evidence from the national study of health and growth 1973–86
BMJ
Changing prevalence of asthma in Australian children
BMJ
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC
Lancet
Strategies for the prevention of atopic asthma
Pediatr Allergy Immunol
Exposure to house dust mite (Der p1) and the development of asthma in childhood: a prospective study
N Engl J Med
Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study
BMJ
Influence of parental smoking on respiratory symptoms during the first decade of life
Am J Epidemiol
Passive smoking as a determinant of bronchial responsiveness in children
Am J Respir Crit Care Med
Role of viral infections in the inception of asthma and allergies during childhood: could they be protective?
Thorax
Skin test reactivity and number of siblings
BMJ
Cited by (0)
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (e-mail: [email protected]).