Chest
Clinical Investigations: COPDEndogenous Hydrogen Sulfide in Patients With COPD
Section snippets
Subjects
Patients were recruited from clinics at Peking University, Third Hospital. The study was approved by the Ethics Committee of Peking University, Third Hospital, and all patients gave their informed consent. Twenty-seven patients with acute exacerbation of COPD (AECOPD; 16 men and 11 women; mean age, 76.7 ± 1.3 years; 14 smokers [36 pack-years], 13 nonsmokers; group 1); 37 patients with stable COPD (29 men and 8 women; age, 65.6 ± 1.6 years; 28 smokers [25 pack-years], 9 nonsmokers; group 2); and
Subject Characteristics
The characteristics of the 77 subjects who participated in the study are inTable 1. Patients with AECOPD were significantly older than patients with stable COPD and healthy control subjects (p < 0.01). FEV1/FVC and proportion of predicted FEV1were significantly lower in patients with AECOPD and stable COPD than in healthy control subjects (p < 0.01).
H2S and NO Levels in Serum
We investigated the effect of age on serum H2S and NO levels in normal control subjects and found no difference among group 4 (71 to 80 years),
DISCUSSION
COPD is characterized by chronic inflammation throughout the airways and parenchymal and pulmonary vasculature. Oxidative stress and imbalances in host defense mechanisms may be among the causes of COPD. NO is an endogenous gasotransmitter involved in many aspects of pulmonary function in health and disease. The increased production of NO during inflammatory immune processes involving the respiratory tract is thought to constitute a host defense mechanism, although this comes at a price,
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This work was supported by National Natural Science Foundation of China grants 30300143 and 30400151.
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