Chest
Original ResearchEffect of Lung Resection on Exercise Capacity and on Carbon Monoxide Diffusing Capacity During Exercise
Section snippets
Materials and Methods
In our previous study,9 a total of 57 patients with non-small cell lung cancer undergoing thoracotomy for lung resection at Vancouver General Hospital from October 1998 to May 1999 were evaluated preoperatively. The study was approved by the University of British Columbia Ethics Review Board, and all patients signed an informed consent form prior to participation.
Details of the lung function tests and exercise studies have been described previously.9 A computerized dry rolling seal spirometer
Results
The 28 patients who had undergone follow-up studies 1 year after undergoing lung resection had a mean (± SD) age of 64.6 ± 10 years; 17 patients (61%) were men, and 11 patients (39%) were women. The mean height was 168 ± 10 cm, and the mean weight was 71 ± 14 kg. The surgical interventions that had been performed were pneumonectomy (5 patients), lobectomy (19 patients), and segmental resection (4 patients). Preoperative data on these 28 patients are shown in Table 1 and are similar to those of
Discussion
The main findings in this study were as follows: (1) the increase in Dlco with exercise was preserved after lobectomy; and (2) the calculation of PPO values for lung function and exercise test results from preoperative test data and the extent of functioning of the resected bronchopulmonary segments yielded acceptable results after lobectomy. Although there was a slight decrease in maximal exercise capacity after lobectomy, there was preservation of the (70%-R)Dlco after lobectomy, indicating
Acknowledgment
The authors thank Drs. Kenneth Evans and Richard Finley for their cooperation in recruiting their patients for the study; Drs. Brian Graham, Jim Potts, and Sundeep Rai for their advice and help in setting up the 3EQ-Dlco technique; Dr. Sverre Vedal for supervising some of the exercise tests and for helpful advice; Dr. Harry Joe for his help with the statistical analysis and graphic presentation of data; and the Lung Function Staff for their help in recruiting patients.
References (21)
- et al.
Clinical course related to preoperative and postoperative pulmonary function inpatients with bronchogenic carcinoma
Chest
(1971) - et al.
Lung scanning and exercise testing for the prediction of postoperative performance in lung resection candidates at increased risk for complications
Chest
(1995) - et al.
Prediction of postoperative respiratory failure in patients undergoing lung resection for lung cancer
Ann Thorac Surg
(1988) - et al.
A method for predicting postoperative lung function and its relation to postoperative complications in patients with lung cancer
Ann Thorac Surg
(1985) - et al.
Effects of lobectomy on lung function
Thorax
(1980) - et al.
Pulmonary function and exercise capacity after lung resection
Eur Respir J
(1996) - et al.
Cardiopulmonary function at rest and during exercise after resection for bronchogenic carcinoma
Ann Thorac Surg
(1997) - et al.
Prediction of postoperative cardiopulmonary function using perfusion scintigraphy in patients with bronchogenic carcinoma
Clin Physiol
(1997) - et al.
Role of exercise diffusing capacity in the preoperative evaluation of patients for lung resection
Am J Respir Crit Care Med
(2000) - et al.
Relationship of predicted postoperative product to postoperative complications [abstract]
Am J Respir Crit Care Med
(2000)
Cited by (0)
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).
Dr. Wang was supported in part by a Fellowship from the British Columbia Lung Association and by funds from the Vancouver General Hospital Foundation. The analyzers and computer for the 3EQ-Dlco were obtained through a grant from the British Columbia Medical Services Foundation, while the SensorMedics exercise equipment was purchased with a major equipment grant from the Tuberculosis and Chest Disabled Veterans Association.