Chest
Volume 71, Issue 2, Supplement, February 1977, Pages 306-307
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Vascular Obstruction Causes Pulmonary Hypertension in Severe Acute Respiratory Failure

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MATERIAL AND METHODS

We used a perfusion technique similar to Sobin et al2 to stereoscopic-ally visualize the pulmonary circulation. Low viscosity silicone polymers were filled with radiopaque colored compounds and 500 ml infused after catalysis at 50-100 mm Hg through the pulmonary artery of six patients anticoagulated at death. No flushing was performed. The trachea was intermittently inflated to 40 cm H2O peak pressure with 10 cm H2O positive end expiratory pressure (PEEP) during perfusion. In order to recruit

RESULTS

Figures 2 and 3 illustrate the dense capillary networks of normal human lungs infused at 50 mm Hg. Figures 4 and 5 illustrate common pathologic findings of a patient with three weeks of ARF and an elevated pulmonary vascular resistance. Figure 4 demonstrates a small infarct (black) due to pulmonary arterial obstruction. In addition, the alveolar capillary network is diffusely diminished. Figure 5 illustrates the destroyed capillary networks of ARF. There are virtually no capillary networks in

REFERENCES (3)

  • BG Barratt-Boyes et al.

    Cardiac output and related measurements and pressure values in the right heart and associated vessels

    J Lab Clin Med

    (1958)
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