Chest
Severe Kyphoscoliosis, Breathing, and Sleep: The “Quasimodo” Syndrome During Sleep
Section snippets
Patient Population
The five patients were all adult men with a mean age of 51 years (range, 43 to 62, Table 1). Their mean weight was 65.6 kg (range 57 to 71), and all were within 5 percent of their ideal weight corrected for age. Two patients (1 and 4) were seen for a complaint of severe daytime sleepiness, and one patient (3) complained of disrupted nocturnal sleep with feelings of tiredness the following day (disorder of maintaining sleep).2 One patient (2) was referred for possible obstructive apnea during
RESULTS
The results of the initial screening polysomnographic studies are presented in Table 2. All patients had apneic events during sleep that were associated with oxygen desaturation. However, the number and type of apneas and amount of desaturation varied in each case. During sleep, all patients presented evidence of apnea and sleep-related hypopnea. Hypopnea has been defined as a decrease in abdominal and thoracic movements, decreased air flow, and a fall in oxygen saturation; when endoesophageal
COMMENT
Patients with severe thoracic deformation are known to have varying degrees of pulmonary disability. A recent review by Bergofsky1 outlined the impact of severe kyphoscoliosis on breathing during wakefulness. As of now, little attention has been given to the effect of kyphoscoliosis on sleep and sleep states in these patients. It is reasonable to suggest that the supine position may well have an impact on the respiratory function of these patients whose upright pulmonary function tests are
REFERENCES (14)
Respiratory failure in disorders of the thoracic cage
Am Rev Respir Dis
(1979)Association of sleep disorders centers: diagnostic classification of sleep and arousal disorders
Sleep
(1979)- et al.
Les formes de transition du syndrome pickwikien: séméiolgie et distribution des apnées
Bull Physiopathol Respir
(1972) - et al.
Continuous recording of the pulmonary and systemic arterial pressure during sleep in syndromes of hypersomnia with periodic breathing
Bull Physiopathol Respir
(1971) - et al.
Hemodynamics in sleep induced apnea: studies during wakefulness and sleep
Ann Intern Med
(1976) - et al.
Respiratory and hemodynamic study during wakefulness and sleep in myotonic dystrophy
Sleep
(1978) Postural and ventilatory functions of intercostal muscles
Acta Neurobiol Exp
(1973)
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This research was supported in part by Public Health Service Research Grant R.R.-70 from the General Clinical Research Centers, Division of Research Resources; and by INSERM to CG.