Chest
Clinical InvestigationsHomogeneity of Bronchopulmonary Distribution of 99mTc Aerosol in Normal Subjects and in Cystic Fibrosis Patients
Section snippets
Protocol
Nine healthy male volunteers, ranging in age from 22 to 29 years, and five patients (four men and one woman) with CF, ranging in age from 18 to 39 years, were studied (Table 1). All subjects were nonsmokers. All patients with CF were followed regularly in the Cystic Fibrosis Clinic, were in clinically stable condition, and were receiving pancreatic enzyme and multivitamin supplements. Patient 2 was also receiving nebulized antibiotic treatment (gentamicin). Patient 3 was also being treated with
RESULTS
Table 1 shows the results of pulmonary function tests for the nine normal volunteers and five patients with CF. The patients with CF were significantly shorter than the normal volunteers, with a mean (±SD) of 66±2 and 70±3 inches, respectively (p = 0.04; unpaired t-test). Baseline FEV1 and FVC (percent predicted) were significantly lower in the patients with CF, with 35 ±13 percent and 55 ±16 percent, respectively, compared to 89 ±11 percent and 95 ±12 percent, respectively, for the normal
DISCUSSION
We compared homogeneity of aerosol distribution in nine normal volunteers and five patients with CF during a clinically stable phase of the disease. Since it is well known that particle size, inspiratory flow rate, pulmonary volume, and residence time are major determinants of regional aerosol deposition in human airways, care was taken to regulate these factors. The radioaerosol consisted of small droplets (MMAD= 1.12µm). Inspiratory flow rate was controlled at 0.5 L/s. Pulmonary volume at the
ACKNOWLEDGMENTS
We thank Ms. Karen Nelson for preparing the manuscript and Mr. Gerard McCormick for technical assistance.
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