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Clinical InvestigationsComparison of Central-Venous to Mixed-Venous Oxygen Saturation During Changes in Oxygen Supply/Demand
Section snippets
METHODS
Thirty-eight mongrel dogs of either sex (av wt, 18 ± 2 kg) were anesthetized with pentobarbital sodium (30 mg/kg IV), with supplemental doses given as needed. They were intubated and ventilated with a Harvard respirator at ten breaths/min and a tidal volume sufficient to maintain arterial PCO2 at 35 to 40 mm Hg. The animals were paralyzed with succinylcholine chloride. Systemic and PA pressures, heart rate, and ECG were continuously recorded.
In the first series of experiments (n = 24)
RESULTS
In vitro O2 Saturation Measurements
The correlation between and ScvO2 for the first series of experiments obtained from intermittent simultaneous blood sampling is shown in Figure 1. The individual correlation coefficients between the two sites for each of 22 dogs ranged from 0.92 to 0.99. The various experimental interventions, from hyperoxia to severe hypoxia, produced a range in venous O2 saturation from greater than 80 percent to less than 10 percent. When changes in O2 saturation
DISCUSSION
The O2 saturation values for the pulmonary artery and superior vena cava were generally in close accordance throughout all the experimental conditions of this study. Furthermore, during abrupt changes in the oxygen supply to demand ratio, changes in ScvO2 matched changes in almost immediately. Hypoxia caused the greatest divergence of values with an average difference of –6 percent saturation and a worse-case difference of –20 percent. ScvO2 was expected to be slightly lower
ACKNOWLEDGMENTS
Fiberoptic catheters and O2 saturation monitors were provided by Baxter Edwards Corp., Irvine, CA. Dopexamine was generously supplied by Fisons plc, Loughborough, UK.
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Supported by NHLBI grants HL14693, HL26927, and 5T32HL0755305, and Braun Melsungen Foundation (Germany).