Pulmonary-Renal Syndrome, Diffuse PulmonaryHemorrhage and Glomerulonephritis, Associatedwith Wegener's Granulomatosis EffectivelyTreated with Early Plasma Exchange Therapy

Toshiro Sugimoto; Naoko Deji; Shinji Kume; Norihisa Osawa; Masayoshi Sakaguchi; Keiji Isshiki; Daisuke Koya; Atsunori Kashiwagi

doi:10.2169/internalmedicine.46.6070

CASE REPORTS

Pulmonary-Renal Syndrome, Diffuse PulmonaryHemorrhage and Glomerulonephritis, Associatedwith Wegener's Granulomatosis EffectivelyTreated with Early Plasma Exchange Therapy

Toshiro Sugimoto, Naoko Deji, Shinji Kume, Norihisa Osawa, Masayoshi Sakaguchi, Keiji Isshiki, Daisuke Koya, Atsunori Kashiwagi

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Keywords: crescentic necrotizing glomerulonephritis, diffuse pulmonary hemorrhage, plasma exchange, pulmonary-renal syndrome, Wegener's granulomatosis

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 1 Pages 49-53

DOI https://doi.org/10.2169/internalmedicine.46.6070

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Abstract

We present a case of a 38-year-old Japanese man with Wegeners granulomatosis complicated with pulmonary-renal syndrome, i.e., diffuse pulmonary hemorrhage and rapidly progressive renal glomerulonephritis. As this is a life-threatening condition, we promptly initiated plasma exchange with intravenous methylprednisolone therapy. Diffuse pulmonary hemorrhage and renal failure were markedly improved. This case merits presentation because there are few clinical studies of the treatment of Wegeners granulomatosis with pulmonary-renal syndrome, particularly with pulmonary hemorrhage.

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