Rhinocerebral mucormycosis diagnosis by aspiration cytology

Diagn Cytopathol. 2000 Aug;23(2):97-100. doi: 10.1002/1097-0339(200008)23:2<97::aid-dc6>3.0.co;2-p.

Abstract

Rhinocerebral mucormycosis is a rapidly progressing, often fatal fungal infection that occurs commonly in diabetics and immunocompromised individuals. We present 2 cases of rhinocerebral mucormycosis with a paranasal mass. One patient had an intracranial extension. Nasal scrapings and fine-needle aspiration cytology (FNAC) of the paranasal masses showed fungal hyphae morphologically resembling Mucor. Surgical material showed features of mucormycosis. FNAC and scrape smears can give a conclusive diagnosis of mucormycosis, and the patient can be treated with appropriate antifungal therapy and surgical debridement. Preoperative cytology is an effective technique to establish a diagnosis of mucormycosis and obviates the need for a preoperative biopsy.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Biopsy, Needle
  • Brain Diseases / drug therapy
  • Brain Diseases / microbiology*
  • Brain Diseases / pathology
  • Debridement
  • Diabetes Complications
  • Humans
  • Male
  • Middle Aged
  • Mucormycosis / drug therapy
  • Mucormycosis / microbiology*
  • Mucormycosis / pathology
  • Paranasal Sinus Diseases / drug therapy
  • Paranasal Sinus Diseases / microbiology*
  • Paranasal Sinus Diseases / pathology
  • Rhizopus / isolation & purification*
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Amphotericin B