Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

Thomas J Papadimos; Azedine Medhkour; Sooraj Yermal

doi:10.1186/1757-7241-17-5

Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

Scand J Trauma Resusc Emerg Med. 2009 Feb 17:17:5. doi: 10.1186/1757-7241-17-5.

Authors

Thomas J Papadimos¹, Azedine Medhkour, Sooraj Yermal

Affiliation

¹ Department of Anesthesiology, College of Medicine, University of Toledo, Toledo, OH 43614, USA. thomas.papadimos@utoledo.edu

Abstract

Use of inhaled nitric oxide in humans with traumatic brain injury and acute respiratory distress syndrome has twice previously been reported to be beneficial. Here we report a third case. We propose that INO may decrease the inflammatory response in patients with increased intracranial pressure caused by traumatic brain injury accompanied by acute respiratory distress syndrome thereby contributing to improved outcomes.

Publication types

Case Reports

MeSH terms

Accidents, Traffic
Adult
Anti-Inflammatory Agents
Brain Injuries / drug therapy
Brain Injuries / physiopathology*
Free Radical Scavengers / administration & dosage
Free Radical Scavengers / pharmacology*
Humans
Intracranial Pressure / drug effects*
Male
Nitric Oxide / administration & dosage
Nitric Oxide / pharmacology*
Respiratory Distress Syndrome / complications*

Substances

Anti-Inflammatory Agents
Free Radical Scavengers
Nitric Oxide