Prolongation of mechanical ventilation poses serious personal and financial threats to healthcare consumers. To that end, many healthcare-related groups have established mechanisms for rapid weaning and subsequent extubation of mechanically ventilated patients. Our objectives were to create and implement an evidenced-based, multidisciplinary care-driven ventilator-weaning protocol as well as revise existing ventilator sedation protocols to decrease length of stay in addition to time spent on the ventilator. Our findings are presented in this article.