The Adverse Impact of Unplanned Extubation in a Cohort of Critically Ill Neonates

Respir Care. 2019 Dec;64(12):1500-1507. doi: 10.4187/respcare.06721. Epub 2019 May 28.

Abstract

Background: We sought to describe adverse events associated with unplanned extubation (UE) and to explore risk factors for serious adverse events post-UE among infants who experienced UE.

Methods: Data were prospectively collected on all infants who had a UE event at a single institution over a 4-y period. Demographic information and information on outcomes were obtained retrospectively. We described the frequency of post-UE adverse events: success or failure of extubation trial if offered, rate of re-intubation, post-UE changes in ventilator settings, and serious adverse events post-UE (eg, need for cardiopulmonary resuscitation, clinical sepsis, and death or tracheostomy prior to discharge). We used a multivariate logistic regression model to identify the risk factors associated with serious adverse events.

Results: There were 134 documented UE events. Agitation was the most common known cause. After UE, 49% of the subjects were given a trial of extubation, and 65% of the trials were successful at 48 h. Cardiopulmonary resuscitation (CPR) was performed in 13% of cases. In subjects requiring immediate re-intubation, mean airway pressure (̄Paw) and oxygen requirement increased in 33% and 55% of the subjects, respectively. Post-UE clinical sepsis occurred in 17% of subjects. Higher pre-UE ̄Paw and difficult re-intubation were associated with a need for CPR. Subjects who received CPR had increased odds (3.7×) of developing clinical sepsis.

Conclusion: UE can result in serious adverse events, including hemodynamic instability and possibly an increased risk for clinical sepsis. Difficult re-intubation was associated with a higher risk of needing CPR and, later, tracheostomy and death.

Keywords: adverse events; newborn; unplanned extubation.

Publication types

  • Evaluation Study

MeSH terms

  • Airway Extubation / adverse effects*
  • Cardiopulmonary Resuscitation / mortality
  • Critical Illness / therapy*
  • Female
  • Humans
  • Infant, Newborn
  • Logistic Models
  • Male
  • Prospective Studies
  • Retrospective Studies
  • Risk Factors