Abstract
Lymphangioleiomyomatosis is a rare cause of pneumothorax in women. We present the case of a 48-year-old woman with lymphangioleiomyomatosis, who had never had a pneumothorax prior to commencing chemotherapy for breast cancer. During chemotherapy she developed 3 pneumothoraces and 2 episodes of pneumomediastinum. We suggest that the pneumothoraces were caused by the chemotherapy. To our knowledge, this is the first reported case of chemotherapy triggering pneumothoraces in a woman with lymphangioleiomyomatosis.
MeSH terms
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Antibodies, Monoclonal / adverse effects
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Antibodies, Monoclonal, Humanized
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Breast Neoplasms / drug therapy*
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Female
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Humans
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Lapatinib
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Lung Neoplasms / complications*
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Lung Neoplasms / therapy
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Lymphangioleiomyomatosis / complications*
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Lymphangioleiomyomatosis / therapy
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Middle Aged
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Neoplasms, Second Primary / drug therapy*
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Oxygen Inhalation Therapy
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Pneumothorax / chemically induced*
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Pneumothorax / complications*
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Quinazolines / adverse effects
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Trastuzumab
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Quinazolines
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Lapatinib
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Trastuzumab