[PDF][PDF] Scavenging of labile heme by hemopexin is a key checkpoint in cancer growth and metastases

…, E Csizmadia, M Palominos, A Stiehm… - Cell reports, 2020 - cell.com
Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of
tumor stroma-expressed Hx in suppressing cancer progression. Labile heme and Hx levels …

[HTML][HTML] STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population

G Canesin, V Maggio, M Palominos, A Stiehm… - Scientific Reports, 2020 - nature.com
Cancer stem cells (CSCs) are a small subpopulation of quiescent cells with the potential to
differentiate into tumor cells. CSCs are involved in tumor initiation and progression and …

Circulating tumor cells as a marker for progression‐free survival in metastatic castration‐naļve prostate cancer

…, A Linder, D Flondell Site, G Canesin, A Stiehm… - The …, 2017 - Wiley Online Library
BACKGROUND Analysis of circulating tumor cells (CTC) is a promising prognostic marker
in castration‐resistant prostate cancer (CRPC). The aim of this study was to investigate CTC …

[HTML][HTML] The STAT3 inhibitor GPB730 enhances the sensitivity to enzalutamide in prostate cancer cells

R Hellsten, A Stiehm, M Palominos, M Persson… - Translational …, 2022 - Elsevier
Enzalutamide is a second-generation anti-androgen which has shown increased survival in
patients with metastatic prostate cancer. However, some patients do not respond to this …

Club cell secretory protein improves survival in a murine obliterative bronchiolitis model

…, K Tram, A Price, K England, A Stiehm… - … of Physiology-Lung …, 2013 - journals.physiology.org
Club cell secretory protein (CCSP) is an indirect phospholipase A2 inhibitor with some
immunosuppressive and antiproliferative properties that is expressed in bronchiolar Club cells. In …

Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel

…, GJ Jaffe, JS Louie, RB Nussenblatt, ER Stiehm… - American journal of …, 2000 - Elsevier
PURPOSE: To provide recommendations for the use of immunosuppressive drugs in the
treatment of patients with ocular inflammatory disorders. PARTICIPANTS: A 12-person panel of …

Update on the use of immunoglobulin in human disease: a review of evidence

…, R Nelson, E Secord, SC Jordan, ER Stiehm… - Journal of Allergy and …, 2017 - Elsevier
Human immunoglobulin preparations for intravenous or subcutaneous administration are the
cornerstone of treatment in patients with primary immunodeficiency diseases affecting the …

[HTML][HTML] mTOR: a cellular regulator interface in health and disease

F Boutouja, CM Stiehm, HW Platta - Cells, 2019 - mdpi.com
The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine
kinase, which has a central function in integrating growth signals and orchestrating their …

Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

…, PL Nara, M Lamacchia, E Garratty, ER Stiehm… - Science, 1994 - science.org
The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency
virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines. A …

Serum levels of immune globulins in health and disease: a survey

ER Stiehm, HH Fudenberg - Pediatrics, 1966 - publications.aap.org
Immune globulins in sera of normal persons of various ages were quantitated by a radial
diffusion technique; the levels changed considerably with age, especially during early infancy. …