Genetics of rheumatoid arthritis: 2018 status
Y Okada, S Eyre, A Suzuki, Y Kochi… - Annals of the rheumatic …, 2019 - ard.bmj.com
Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the
discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci …
discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci …
A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non-European …
populations and scope of phenotypes. To expand an atlas of genetic associations in non-European …
Genetics of rheumatoid arthritis contributes to biology and drug discovery
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …
variants with diverse genomic and biological data sets to provide insight into …
Genetics of rheumatoid arthritis: underlying evidence of ethnic differences
Y Kochi, A Suzuki, R Yamada, K Yamamoto - Journal of autoimmunity, 2009 - Elsevier
A new age has begun in the genetics of rheumatoid arthritis (RA), as genome-wide association
studies scanning the human genome have been put into practical use. Among the RA-…
studies scanning the human genome have been put into practical use. Among the RA-…
Citrullination by peptidylarginine deiminase in rheumatoid arthritis
A Suzuki, R Yamada… - Annals of the New York …, 2007 - Wiley Online Library
Rheumatoid arthritis (RA) is a complex, multifactorial disease with genetic and immunological
aspects. Because RA is an autoimmune condition, dysregulation of the immune system is …
aspects. Because RA is an autoimmune condition, dysregulation of the immune system is …
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
A Suzuki, R Yamada, X Chang, S Tokuhiro, T Sawada… - Nature …, 2003 - nature.com
Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (…
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (…
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
…, X Chang, A Suzuki, Y Kochi, T Sawada, M Suzuki… - Nature …, 2003 - nature.com
Rheumatoid arthritis is a common inflammatory disease with complex genetic components.
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …
To elucidate disease biology in the East Asian population, we conducted a genome-wide …
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here
we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family…
we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family…
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation.
We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese …
We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese …