Individualized positive end-expiratory pressure in obese patients during general anaesthesia: a randomized controlled clinical trial using electrical impedance …

…, LM Camilo, A Beda, AR Carvalho… - BJA: British Journal …, 2017 - academic.oup.com
Background. General anaesthesia leads to atelectasis, reduced end-expiratory lung volume
(EELV), and diminished arterial oxygenation in obese patients. We hypothesized that a …

Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury

PM Spieth, AR Carvalho, P Pelosi, C Hoehn… - American journal of …, 2009 - atsjournals.org
Rationale: Noisy ventilation with variable Vt may improve respiratory function in acute lung
injury. Objectives: To determine the impact of noisy ventilation on respiratory function and its …

Noisy pressure support ventilation: a pilot study on a new assisted ventilation mode in experimental lung injury

…, PM Spieth, P Pelosi, AR Carvalho… - Critical care …, 2008 - journals.lww.com
Objective: To describe and evaluate the effects of the new noisy pressure support ventilation
(noisy PSV) on lung physiologic variables. Design: Crossover design with four modes of …

[HTML][HTML] Non-lobar atelectasis generates inflammation and structural alveolar injury in the surrounding healthy tissue during mechanical ventilation

J Retamal, BC Bergamini, AR Carvalho, FA Bozza… - Critical care, 2014 - Springer
Introduction When alveoli collapse the traction forces exerted on their walls by adjacent
expanded units may increase and concentrate. These forces may promote its re-expansion at …

[HTML][HTML] Ability of dynamic airway pressure curve profile and elastance for positive end-expiratory pressure titration

AR Carvalho, PM Spieth, P Pelosi, MF Vidal Melo… - Intensive care …, 2008 - Springer
Objective To evaluate the ability of three indices derived from the airway pressure curve for
titrating positive end-expiratory pressure (PEEP) to minimize mechanical stress while …

Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation of pressure …

…, M Kasper, R Schubert, NC Carvalho… - Critical care …, 2011 - journals.lww.com
Objectives: To explore whether 1) conventional pressure support ventilation improves lung
function and attenuates the pulmonary inflammatory response compared to pressure-…

Regional tidal lung strain in mechanically ventilated normal lungs

…, M Gama de Abreu, AR Carvalho… - Journal of Applied …, 2016 - journals.physiology.org
Parenchymal strain is a key determinant of lung injury produced by mechanical ventilation.
However, imaging estimates of volumetric tidal strain (ε = regional tidal volume/reference …

Effects of different levels of pressure support variability in experimental lung injury

PM Spieth, AR Carvalho, A Güldner… - The Journal of the …, 2009 - pubs.asahq.org
Background Noisy pressure support ventilation has been reported to improve respiratory
function compared to conventional assisted mechanical ventilation. We aimed at determining …

Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury

AR Carvalho, PM Spieth, A Güldner… - Journal of applied …, 2011 - journals.physiology.org
In acute lung injury (ALI), pressure support ventilation (PSV) may improve oxygenation
compared with pressure-controlled ventilation (PCV), and benefit from random variation of …

Pressure support ventilation and biphasic positive airway pressure improve oxygenation by redistribution of pulmonary blood flow

AR Carvalho, PM Spieth, P Pelosi, A Beda… - Anesthesia & …, 2009 - journals.lww.com
BACKGROUND: Spontaneous breathing (SB) activity may improve gas exchange during
mechanical ventilation mainly by the recruitment of previously collapsed regions. Pressure …