Background Severe sepsis is common and often fatal. The expanding armamentarium of
evidence-based therapies has improved the outcomes of persons with this disease. However, …

FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian β-tubulin
that polymerizes and assembles into a ring to initiate cell division. We have created a …

Importance There is a major need for effective, well-tolerated treatments for idiopathic
pulmonary fibrosis (IPF). Objective To assess the efficacy and safety of the autotaxin inhibitor …

Extensive research has shown that increased consumption of long-chain omega-3
polyunsaturated fatty acids (n-3 LCPUFAs), namely α-linolenic acid (ALA), eicosapentaenoic acid (…

Results The annual frequency of PE was 527 per 100,000, 204 per 100,000, and 66 per
100,000 persons with ESRD, CKD, and NKF, respectively. In-hospital mortality was higher for …

Purpose: Admission serum bilirubin levels have been incorporated into severity of illness
scoring systems in critical illness as a marker of liver dysfunction. The purpose of our study is to …

Background Pulmonary embolism is a common, often fatal condition that requires timely
recognition and rapid institution of therapy. Previous studies have documented worse outcomes …

Rationale: Indeterminate peripheral pulmonary lesions (PPLs) often require tissue diagnosis.
If nonsurgical biopsy techniques are considered, deciding between bronchoscopic …

Rationale: Understanding the changing incidence and impact of acute kidney injury requiring
dialysis in patients with severe sepsis will allow better risk stratification, design of clinical …

Objective: Severe sepsis requires timely management and has high mortality if care is delayed.
Hematopoietic stem cell transplant recipients are more likely to be immunocompromised …