Background TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates
the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 …

BACKGROUND: Noninvasive ventilation (NIV) titration may be difficult when dynamic
airway obstruction episodes persist, even with high expiratory positive airway pressure (EPAP). …

Background Recessive mutations in the thymidine kinase 2 (TK2) gene cause a rare
mitochondrial myopathy, frequently with severe respiratory involvement. Deoxynucleoside therapy …

OBJECTIVE: To describe the clinical characteristics and risk factors of patients with chest
trauma, and to evaluate their correlation with the development of complications. METHODS: …

Introduction and objectives Humidification and non-invasive ventilation are frequently used
together, despite the lack of precise recommendations regarding this practice. We aimed to …

Although pulmonary and disseminated cryptococcal infection are not uncommon, particularly
in the immunocompromised population, only twice has infection with C. neoformans been …

High-flow nasal cannula (HFNC) is a respiratory support technique that delivers a controlled
concentration of oxygen with high flow, heat, and humidity via the nasal pathway. As it has …

Purpose The European Task Force for chronic non-invasive ventilation in stable COPD
recommends the use of high pressure-support (PS) level to maximize the decrease in PaCO2. It …

… Author links open overlay panel Ana Hernández Voth , Javier Sayas Catalán , Pedro
Benavides Mañas , Alicia de Pablo Gafas , Trinidad Díaz Cambriles , Victoria Villena Garrido …

This historical cohort study evaluated clinical characteristics of progression and prognosis in
adults with thymidine kinase 2 deficiency (TK2d). Records were available for 17 untreated …