Background Severe cardiogenic pulmonary edema is a frequent cause of respiratory failure,
and many patients with this condition require endotracheal intubation and mechanical …

… Correspondence and requests for reprints should be addressed to Andrew D. Bersten,
Department of Critical Care Medicine, Flinders Medical Centre, Adelaide, South Australia. E-mail: …

Background Non-invasive positive pressure ventilation (NIPPV), using continuous positive
airway pressure (CPAP) or bilevel ventilation, has been shown to reduce the need for …

Background: Since publication of the 2012 Berlin definition of acute respiratory distress
syndrome (ARDS), several developments have supported the need for an expansion of the …

Introduction: Sleep disturbance is a frequently overlooked complication of intensive care unit
(ICU) stay. Aim: To evaluate sleep quality among patients admitted to ICU and investigate …

… The right of Andrew D Bersten and Neil Soni to be identified as authors of this work has
been asserted by them in accordance with the Copyright, Designs and Patents Act 1988. …

PURPOSE: Dynamometry is an objective tool for volitional strength evaluation that may
overcome the limited sensitivity of the Medical Research Council scale for manual muscle tests, …

Background and objective: Reliable measurement of diaphragm and peripheral muscle
thickness, using diagnostic ultrasound, has only been validated in the erect posture. However, in …

Background Skeletal muscle wasting and weakness are common in patients with sepsis in
the intensive care unit, although less is known about deficits in diaphragm and limb muscles …

Introduction Current low (stress) dose corticosteroid regimens may have therapeutic
advantage in severe sepsis and septic shock despite conflicting results from two landmark …