Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving
primarily motor neurons in the cerebral cortex, brainstem and spinal cord. The variability in …

Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that
primarily affects upper and lower motor neurons, but also frontotemporal and other regions of …

PML is a progressive opportunistic infection of the CNS caused by a commonly occurring virus
that may become manifest in the context of reduced host resistance in persons of any age…

Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive weakness
and neuropathologically by loss of motor neurons. Phenotypically, there is marked …

Objective To evaluate dextromethorphan combined with ultra low‐dose quinidine (DMq) for
treating pseudobulbar affect (PBA) in patients with amyotrophic lateral sclerosis (ALS) or …

Objective To compare the effect of riluzole on median survival in population studies of patients
with amyotrophic lateral sclerosis (ALS) with that observed in clinical trials. Methods: Two …

Objective To revise the 1999 Airlie House consensus guidelines for the design and
implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (…

Stages in the development of ALS. ALS is a disease that may have a preclinical and a clinical
phase (see Appendix). The low frequency of ALS suggests an inherent susceptibility in …

Background We aimed to evaluate overall survival in US patients with amyotrophic lateral
sclerosis (ALS) treated with intravenous (IV) edaravone compared with those not treated with …

Amyotrophic lateral sclerosis (ALS) is a lethal, progressive neurodegenerative disease
characterized by loss of motor neurons. Patients with ALS lose function in the limbs, speech, …