A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was
facilitated by the European Respiratory Society (ERS) and the International Society for …

This international task force report updates general considerations for bronchial challenge
testing and the performance of the methacholine challenge test. There are notable changes …

… Beth L Laube PhD currently holds stock options in Nektar Therapeutics. She has been a …
Beth L Laube PhD presented a version of this article at the 36th RESPIRATORY CARE Journal …

The nasal cavity has a large surface area (150 cm^ sup 2^) available for drug targeting (1).
Gamma scintigraphy has been used as a tool to evaluate nasal deposition of radiolabeled …

Recently, this international task force reported the general considerations for bronchial
challenge testing and the performance of the methacholine challenge test, a “direct” airway …

Two-dimensional (2D or planar) imaging with 99m Tc radiolabels enables quantification of
whole-lung and regional lung depositions for orally inhaled drug products. This article …

Theoretically, cystic fibrosis transmembrane conductance regulator (CFTR) gene replacement
during the neonatal period can decrease morbidity and mortality from cystic fibrosis (CF). …

Compared to research into aerosolized delivery of drugs to treat lung disease, research into
nasal delivery of aerosolized drugs to treat sinusitis has been significantly neglected. This is …

Current concepts of cystic fibrosis (CF) pathophysiology link ion transport abnormalities to
reduced airway surface liquid (ASL) hydration and impaired mucus clearance. It is likely that …

BACKGROUND. The ability to restore cystic fibrosis transmembrane regulator (CFTR)
function with effective small molecule modulators in patients with cystic fibrosis provides an …