User profiles for Bruce K Rubin

Bruce K. Rubin

Virginia Commonwealth University School of Medicine
Verified email at vcu.edu
Cited by 20785

Managing cough as a defense mechanism and as a symptom: a consensus panel report of the American College of Chest Physicians

…, RH Poe, UBS Prakash, MR Pratter, BK Rubin - Chest, 1998 - journal.chestnet.org
1. Cough can (a) be an important defense mechanism to help clear excessive secretions
and foreign material from airways;(b) be an important factor in the spread of infection;(c) …

Mechanisms of action and clinical application of macrolides as immunomodulatory medications

S Kanoh, BK Rubin - Clinical microbiology reviews, 2010 - Am Soc Microbiol
Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …

Mucins, mucus, and sputum

JA Voynow, BK Rubin - Chest, 2009 - Elsevier
Normal airway mucus lines the epithelial surface and provides an important innate immune
function by detoxifying noxious molecules and by trapping and removing pathogens and …

COVID-19 and telehealth, education, and research adaptations

…, V Mishra, PLP Brand, BK Rubin - Paediatric respiratory …, 2020 - Elsevier
For decades, there have been government funded services to provide healthcare telephonically
to remote sites both on the earth and in the air. This capability has evolved into what we …

Problems with inhaler use: a call for improved clinician and patient education

JB Fink, BK Rubin - Respiratory care, 2005 - rc.rcjournal.com
Patient education is a critical factor in the use and misuse of medication inhalers. Inhalers
represent advanced technology that is considered so easy to use that many patients and …

Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA

T Suzuki, T Sakagami, BK Rubin, LM Nogee… - The Journal of …, 2008 - rupress.org
Primary pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by accumulation
of surfactant in the lungs that is presumed to be mediated by disruption of granulocyte/…

Mucins, mucus, and goblet cells

J Ma, BK Rubin, JA Voynow - Chest, 2018 - Elsevier
The respiratory epithelium is lined by mucus, a gel consisting of water, ions, proteins, and
macromolecules. The major macromolecular components of mucus are the mucin …

Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action

M Shinkai, MO Henke, BK Rubin - Pharmacology & therapeutics, 2008 - Elsevier
Macrolide antibiotics administered in sub-antimicrobial doses improve pulmonary function
and decrease exacerbation frequency for persons with diffuse panbronchiolitis or cystic …

AARC clinical practice guideline: effectiveness of nonpharmacologic airway clearance therapies in hospitalized patients

SL Strickland, BK Rubin, GS Drescher, CF Haas… - Respiratory …, 2013 - rc.rcjournal.com
Airway clearance therapy (ACT) is used in a variety of settings for a variety of ailments.
These guidelines were developed from a systematic review with the purpose of determining …

Mucolytics, expectorants, and mucokinetic medications

BK Rubin - Respiratory Care, 2007 - rc.rcjournal.com
In health, the airways are lined by a layer of protective mucus gel that sits atop a watery
periciliary fluid. Mucus is an adhesive, viscoelastic gel, the biophysical properties of which are …