Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: comparison of Andersen 8-stage cascade impactor, next generation …

JP Mitchell, MW Nagel, KJ Wiersema, CC Doyle - AAPS PharmSciTech, 2003 - Springer
The purpose of this research was to compare three different methods for the aerodynamic
assessment of (1) chloroflurocarbon (CFC)-fluticasone propionate (Flovent), (2) CFC-sodium …

Relative precision of inhaler aerodynamic particle size distribution (APSD) metrics by full resolution and abbreviated Andersen cascade impactors (ACIs): part 1

JP Mitchell, MW Nagel, CC Doyle, RS Ali… - Aaps Pharmscitech, 2010 - Springer
The purpose of this study was to compare relative precision of two different abbreviated
impactor measurement (AIM) systems and a traditional multi-stage cascade impactor (CI). The …

The importance of nonelectrostatic materials in holding chambers for delivery of hydrofluoroalkane albuterol

…, MW Nagel, VI Avvakoumova, CC Doyle… - Respiratory …, 2006 - rc.rcjournal.com
INTRODUCTION: Electrostaticattraction of aerosolized particles to the inner walls of an
aerosol holding chamber (HC) made from a nonconducting material can reduce medication …

Relative precision of inhaler aerodynamic particle size distribution (APSD) metrics by full resolution and abbreviated Andersen cascade impactors (ACIs): part 2 …

JP Mitchell, MW Nagel, CC Doyle, RS Ali… - AAPS …, 2010 - Springer
The purpose of this study was to resolve an anomalously high measure of extra-fine particle
fraction (EPF) determined by the abbreviated cascade impactor possibly relevant for human …

A novel, versatile valved holding chamber for delivering inhaled medications to neonates and small children: laboratory simulation of delivery options

RM DiBlasi, DP Coppolo, MW Nagel, CC Doyle… - Respiratory …, 2010 - rc.rcjournal.com
BACKGROUND: Delivery of bronchodilator to infants and small children from a pressurized
metered-dose inhaler with valved holding chamber (pMDI-VHC) is limited by airway …

The delivery of chlorofluorocarbon-propelled versus hydrofluoroalkane-propelled beclomethasone dipropionate aerosol to the mechanically ventilated patient: a …

JP Mitchell, MW Nagel, KJ Wiersema, CC Doyle… - Respiratory …, 2003 - rc.rcjournal.com
We describe a laboratory investigation comparing the delivery of chlorofluorocarbon (CFC)-
and hydrofluoroalkane (HFA)-formulated beclomethasone dipropionate (BDP) by metered-…

An in vitro study to investigate the use of a breath-actuated, small-volume, pneumatic nebulizer for the delivery of methacholine chloride bronchoprovocation agent

JP Mitchell, MW Nagel, SL Bates, CC Doyle - Respiratory care, 2003 - rc.rcjournal.com
BACKGROUND: Current American Thoracic Society and American Association for Respiratory
Care guidelines for the delivery of aerosol agents such as methacholine chloride (MC) for …

Can salbutamol be used as a proxy for methacholine when assessing nebuliser performance for a methacholine challenge test?

AL Coates, M Reyna-Vargas, CC Doyle… - European Respiratory …, 2023 - Eur Respiratory Soc
Extract In 2017 the European Respiratory Society/American Thoracic Society [1] recommended
moving to a provocative dose causing a 20% decrease in forced expiratory volume in 1 s …

[PDF][PDF] An in vitro investigation of common nebulizer dosing protocols, comparing a breathactuated with conventional pneumatic small volume nebulizer (SVN)

MW Nagel, CC Doyle, SL Bates… - … drug delivery VIII …, 2002 - researchgate.net
C u m u la tiv e … C u m u la tiv e … C u m …

ARE FIRST AND SECOND GENERATION, MECHANICALLY-OPERATED BREATH-ACTUATED NEBULIZERS (BAN) COMPARABLE BASED ON IN VITRO …

JN Schmidt, J Pevler, CC Doyle, KJ Wiersema… - Respir …, 2005 - researchgate.net
… Schmidt, Jennifer Pevler, Cathy C. Doyle, Kimberly J. Wiersema, Mark W. Nagel and
Jolyon P. … • temperature in range 22 ± 2C