OBJECTIVE: Acute clinical deterioration preceding death is a common observation in patients
with advanced interstitial lung disease and secondary pulmonary hypertension. Patients …

Long-term success in xenotransplantation is currently hampered by acute vascular rejection.
The inciting cause of acute vascular rejection is not yet known; however, a variety of …

Prior work has shown that transforming growth factor-β (TGF-β) can mediate transition of
alveolar type II cells into mesenchymal cells in mice. Evidence this occurs in humans is limited …

Rationale: In 2005, lung allocation for transplantation in the United States changed from a
system based on waiting time to a system based on the Lung Allocation Score (LAS). …

BACKGROUND: Heart failure is a growing epidemic, and a typical aspect of heart failure
pathophysiology is altered calcium transients. Normal cardiac calcium transients are initiated by …

Venovenous extracorporeal membrane oxygenation (VV ECMO) is a therapeutic option to
bridge patients with advanced lung disease to lung transplantation. The use of VV ECMO …

The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation
was reported for the first time more than three decades ago; nevertheless, its use in lung …

Heart failure is associated with pump dysfunction and remodeling but it is not yet known if
the condition affects different transmural regions of the heart in the same way. We tested the …

Xenoreactive natural antibodies in humans and higher primates are directed predominantly
at galα1–3Gal. These antibodies are thought to initiate hyperacute rejection of porcine organ …

An obligately asexual population of Artemia parthenogenetica at Salin de Giraud, France
consists of numerous clones that are genetically and ecologically divergent. The clones are …