[PDF][PDF] Metabolic competition in the tumor microenvironment is a driver of cancer progression
CH Chang, J Qiu, D O'Sullivan, MD Buck, T Noguchi… - Cell, 2015 - cell.com
Failure of T cells to protect against cancer is thought to result from lack of antigen recognition,
chronic activation, and/or suppression by other cells. Using a mouse sarcoma model, we …
chronic activation, and/or suppression by other cells. Using a mouse sarcoma model, we …
[HTML][HTML] Posttranscriptional control of T cell effector function by aerobic glycolysis
A "switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T
cell activation and is thought to be required to meet the metabolic demands of proliferation. …
cell activation and is thought to be required to meet the metabolic demands of proliferation. …
Fueling immunity: insights into metabolism and lymphocyte function
Background Naļve lymphocytes circulate in the body in a resting state, but upon recognition
of foreign antigen and receipt of proper costimulatory signals, these cells become activated, …
of foreign antigen and receipt of proper costimulatory signals, these cells become activated, …
Highly efficient blue-emitting iridium (III) carbene complexes and phosphorescent OLEDs
… Chiung-Fang Chang 1 , Yi-Ming Cheng, Yun Chi, Yuan-Chieh Chiu, Chao-Chen Lin,
Gene-Hsiang Lee, Pi-Tai Chou, Chung-Chia Chen, Chih-Hao Chang, Chung-Chih Wu …
Gene-Hsiang Lee, Pi-Tai Chou, Chung-Chia Chen, Chih-Hao Chang, Chung-Chih Wu …
A robust and accurate approach to computing compressible multiphase flow: Stratified flow model and AUSM+-up scheme
In this paper, we propose a new approach to compute compressible multifluid equations.
Firstly, a single-pressure compressible multifluid model based on the stratified flow model is …
Firstly, a single-pressure compressible multifluid model based on the stratified flow model is …
[PDF][PDF] Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
GJW van der Windt, B Everts, CH Chang, JD Curtis… - Immunity, 2012 - cell.com
CD8 + T cells undergo major metabolic changes upon activation, but how metabolism
influences the establishment of long-lived memory T cells after infection remains a key question. …
influences the establishment of long-lived memory T cells after infection remains a key question. …
[HTML][HTML] Mitochondrial dynamics controls T cell fate through metabolic programming
…, D O'Sullivan, RIK Geltink, JD Curtis, CH Chang… - Cell, 2016 - cell.com
Activated effector T (T E ) cells augment anabolic pathways of metabolism, such as aerobic
glycolysis, while memory T (T M ) cells engage catabolic pathways, like fatty acid oxidation (…
glycolysis, while memory T (T M ) cells engage catabolic pathways, like fatty acid oxidation (…
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
…, E Amiel, SCC Huang, AM Smith, CH Chang… - Nature …, 2014 - nature.com
The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs).
However, the metabolic requirements that support this process remain poorly defined. We …
However, the metabolic requirements that support this process remain poorly defined. We …
[HTML][HTML] Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
…, SCC Huang, JD Curtis, CH Chang… - Immunity, 2014 - cell.com
Generation of CD8 + memory T cells requires metabolic reprogramming that is characterized
by enhanced mitochondrial fatty-acid oxidation (FAO). However, where the fatty acids (FA) …
by enhanced mitochondrial fatty-acid oxidation (FAO). However, where the fatty acids (FA) …
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
…, MD Buck, JD Curtis, CH Chang… - Proceedings of the …, 2013 - National Acad Sciences
A characteristic of memory T (T M ) cells is their ability to mount faster and stronger responses
to reinfection than naļve T (T N ) cells do in response to an initial infection. However, the …
to reinfection than naļve T (T N ) cells do in response to an initial infection. However, the …