Background In patients with the acute respiratory distress syndrome, massive alveolar
collapse and cyclic lung reopening and overdistention during mechanical ventilation may …

Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular
diseases. Recent studies have identified the transcriptional coactivator peroxisome …

The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-γ
coactivator-1α (PGC-1α) was targeted in mice. PGC-1α null (PGC-1α −/− ) mice were …

Alveolar overdistention and cyclic reopening of collapsed alveoli have been implicated in
the lung damage found in animals submitted to artificial ventilation. To test whether these …

Recent evidence has identified the peroxisome proliferator-activated receptor γ coactivator-1α
(PGC-1α) as a regulator of cardiac energy metabolism and mitochondrial biogenesis. We …

Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to
meet the high-energy demands after birth. PPARγ coactivator-1 (PGC-1) α and β have been …

Background— Obesity and diabetes mellitus are complex metabolic problems of pandemic
proportion, contributing to significant cardiovascular mortality. Recent studies have shown …

The aim of the current study was to investigate the influence of static stretching on hamstring
flexibility in healthy young adults by means of systematic review and meta-analysis. The …

Mitochondria have their own DNA (mtDNA) and hence biogenesis of mitochondria requires
a coordination of nuclear and mtDNA, both of which encode for mitochondria proteins. Our …

From the dawning instance of conception to the waning moments of senescence, the human
body exists in a continuum to nourish itself. Man, as a living entity, is in reality a reflection of …