Fusion between transcription factor CBFβ/PEBP2β and a myosin heavy chain in acute myeloid leukemia

P Liu, SA Tarlé, A Hajra, DF Claxton, P Marlton… - Science, 1993 - science.org
The pericentric inversion of chromosome 16 [inv(16)(p13q22)] is a characteristic karyotypic
abnormality associated with acute myeloid leukemia, most commonly of the M4Eo subtype. …

A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403

…, G Marcucci, M Liedtke, DF Claxton… - Blood, The Journal …, 2019 - ashpublications.org
Retrospective studies have suggested that older adolescents and young adults (AYAs) with
acute lymphoblastic leukemia (ALL) have better survival rates when treated using a pediatric …

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan–Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

SM O'Brien, DF Claxton, M Crump… - Blood, The Journal …, 2009 - ashpublications.org
Obatoclax mesylate is a small molecule pan–Bcl-2 antagonist with in vitro activity against
chronic lymphocytic leukemia (CLL) cells. Obatoclax was administered to patients with …

T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T-Cell Exhaustion and Poor Clinical Outcome in AML Patients

Y Kong, L Zhu, TD Schell, J Zhang, DF Claxton… - Clinical Cancer …, 2016 - AACR
Purpose: T-cell immunoglobulin and immunoreceptor tyrosine–based inhibitory motif (ITIM)
domain (TIGIT) is a recently identified T-cell coinhibitory receptor. In this study, we aimed to …

Outcomes of CLL patients treated with sequential kinase inhibitor therapy: a real world experience

…, CS Zent, T Feldman, A Goy, DF Claxton… - Blood, The Journal …, 2016 - ashpublications.org
B-cell receptor kinase inhibitor (KI) therapy represents a paradigm shift in chronic lymphocytic
leukemia (CLL) management, but data on practice patterns after KI discontinuation and …

Targeted Indocyanine-Green-Loaded Calcium Phosphosilicate Nanoparticles for In Vivo Photodynamic Therapy of Leukemia

…, NR Keasey, JH Adair, TP Loughran Jr, DF Claxton… - ACS …, 2011 - ACS Publications
Leukemia is one of the most common and aggressive adult cancers, as well as the most
prevalent childhood cancer. Leukemia is a cancer of the hematological system and can be …

Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer.

…, SA Giralt, BS Andersson, DF Claxton… - Journal of clinical …, 1998 - ascopubs.org
PURPOSE To evaluate the feasibility of allogeneic peripheral-blood progenitor-cell (PBPC)
transplantation and to assess graft-versus-tumor effects in patients with metastatic breast …

Expression of unusual immunophenotype combinations in acute myelogenous leukemia

CL Reading, EH Estey, YO Huh, DF Claxton… - 1993 - ashpublications.org
Immunophenotypes for 272 patients with acute myelogenous leukemia (AML) were analyzed
using a panel of 22 antibodies. Numerical evidence for unusual coexpressions (present in …

Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia

…, JC Liang, U Popat, DF Claxton… - Blood, The Journal …, 1997 - ashpublications.org
The success of adoptive immunotherapy for the treatment of leukemia depends on the
generation of T cells that can specifically react with malignant cells. Dendritic cells (DCs) are …

Apoptosis: molecules and mechanisms

…, S Zhao, Z Xie, H Segall, A Younes, DF Claxton… - Drug Resistance in …, 1999 - Springer
This review of the molecules and pathways involved in programmed cell death (apoptosis)
discriminates triggers of apoptosis (eg chemotherapy, radiation, Fas ligation), modulators of …