Ionic immune suppression within the tumour microenvironment limits T cell effector function

…, Z Yu, V Carbonaro, K Okkenhaug, DS Schrump… - Nature, 2016 - nature.com
Tumours progress despite being infiltrated by tumour-specific effector T cells 1 . Tumours
contain areas of cellular necrosis, which are associated with poor survival in a variety of …

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

…, WR Richli, M Savin, DS Schrump… - Journal of the …, 1999 - academic.oup.com
BACKGROUND: Preclinical studies in animal models have demonstrated tumor regression
following intratumoral administration of an adenovirus vector containing wild-type p53 …

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

…, DM Nguyen, GA Chen, DS Schrump - Journal of the …, 2002 - academic.oup.com
Background: Histone deacetylases (HDACs) modulate chromatin structure by regulating
acetylation of core histone proteins. HDAC inhibitors, such as depsipeptide FR901228 (FK228), …

Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus

…, CPN Dinney, GL Walsh, DS Schrump… - The annals of thoracic …, 1997 - Elsevier
Background. The optimal management of patients with renal cell carcinoma with inferior vena
cava tumor thrombus remains unresolved. Traditional approaches have included resection …

[PDF][PDF] Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy

…, DC Palmer, S Mitra, M Rao, K Keyvanfar, DS Schrump… - Cell metabolism, 2016 - cell.com
Long-term survival and antitumor immunity of adoptively transferred CD8 + T cells is
dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on …

[HTML][HTML] A spectrum of severe familial liver disorders associate with telomerase mutations

RT Calado, JA Regal, DE Kleiner, DS Schrump… - PloS one, 2009 - journals.plos.org
Background Telomerase is an enzyme specialized in maintaining telomere lengths in highly
proliferative cells. Loss-of-function mutations cause critical telomere shortening and are …

Prospective study of thymic carcinoids in patients with multiple endocrine neoplasia type 1

F Gibril, YJ Chen, DS Schrump… - The Journal of …, 2003 - academic.oup.com
Little is known of the natural history of thymic carcinoids in multiple endocrine neoplasia
type 1 (MEN1). This is important because in 1993 they were identified as a frequent cause of …

Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura

DS Schrump, MR Fischette, DM Nguyen, M Zhao… - Clinical Cancer …, 2006 - AACR
Purpose: The DNA methylation paradox, manifested as derepression of cancer-testis
antigens, and silencing of tumor suppressors during malignant transformation, provides the …

Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer

…, ME Dudley, F Liu, DS Schrump… - Blood, The Journal …, 2012 - ashpublications.org
CD4 + FoxP3 + regulatory T cells (Tregs) have been shown to suppress T cell–mediated host
immune responses against self- and nonself-antigens; however, the impact of CD4 + Tregs …

[HTML][HTML] Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells

…, ZA Borman, P Muranski, E Wang, DS Schrump… - Nature …, 2011 - nature.com
The transcriptional repressor Blimp-1 promotes the differentiation of CD8 + T cells into short-lived
effector cells (SLECs) that express the lectin-like receptor KLRG-1, but how it operates …