Background Previous trials involving patients with the acute respiratory distress syndrome (ARDS)
have failed to show a beneficial effect of prone positioning during mechanical …

Background Whether the route of early feeding affects outcomes of patients with severe
critical illnesses is controversial. We hypothesised that outcomes were better with early first-line …

Background There is insufficient research into the use of mechanical ventilation with increased
inspiratory oxygen concentration (FiO 2 ) and fluid resuscitation with hypertonic saline …

BACKGROUND: The aim of this study was to evaluate the clinical efficacy of humidified
oxygen via high-flow nasal cannula (HFNC) alternating with noninvasive ventilation (NIV) in …

Importance Despite advances in care, mortality and morbidity remain high in adults with
acute bacterial meningitis, particularly when due toStreptococcus pneumoniae. Induced …

Importance The benefit of high-flow nasal cannula oxygen (high-flow oxygen) in terms of
intubation and mortality in patients with respiratory failure due to COVID-19 is controversial. …

Background Non-invasive ventilation has never been compared with high-flow oxygen to
determine whether it reduces the risk of severe hypoxaemia during intubation. We aimed to …

Background The optimal calorie and protein intakes at the acute phase of severe critical
illness remain unknown. We hypothesised that early calorie and protein restriction improved …

Background Although non-invasive ventilation (NIV) is recommended for immunocompromised
patients with acute respiratory failure in the intensive care unit (ICU), it might have …

Purpose Skin mottling is frequent and can be associated with an increased mortality rate in
ICU patients with septic shock. Its overall incidence in ICU and its impact on outcome is …