Physiologically based pharmacokinetic modeling in regulatory decision‐making at the European Medicines Agency

E Luzon, K Blake, S Cole, A Nordmark… - Clinical …, 2017 - Wiley Online Library
Physiologically based pharmacokinetic (PBPK) modeling is a valuable tool in drug development
and regulatory assessment, as it offers the opportunity to simulate the pharmacokinetics …

Tracheostomy tube in place at intensive care unit discharge is associated with increased ward mortality

…, R Cuena, P Lopez-Reina, S Zamora, E Luzon - Respiratory …, 2009 - rc.rcjournal.com
OBJECTIVE: To determine the relationship between tracheostomy tube in place after
intensive-care-unit (ICU) discharge and hospital mortality. METHODS: We conducted a prospective …

[HTML][HTML] Achieving clinical outcomes with benralizumab in severe eosinophilic asthma patients in a real-world setting: orbe II study

…, F Casas-Maldonado, E Martínez-Moragón… - Respiratory …, 2023 - Springer
… Data were obtained retrospectively from the electronic medical records of the 15 participating
asthma units. The index date was defined as the date of the first dose of benralizumab, …

Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates …

G Esteso, E Luzón, E Sarmiento… - The Journal of …, 2014 - journals.aai.org
Proteolytic shedding of ligands for the NK group 2D (NKG2D) receptor is a strategy used by
tumors to modulate immune recognition by NK cells and cytotoxic T cells. A number of …

European regulatory perspective on pediatric physiologically based pharmacokinetic models

S Cole, JL Hay, E Luzon, A Nordmark… - International journal of …, 2017 - Future Science
… list of products which actually include PBPK modeling in their PIPs or pediatric developments
is more extensive, as confirmed by a review of the documents stored at the EMA electronic

Intraband and interband absorption of femtosecond laser pulses in copper

…, Z Henis, E Moshe, Y Horovitz, E Luzon… - Laser and Particle …, 2005 - cambridge.org
We investigated the optical properties of pure copper irradiated by a femtosecond laser
pulse. Self-absorption of 50-fs laser pulses at 800 nm and 400 nm wavelengths (below and …

The early phase of the minute ventilation recovery curve predicts extubation failure better than the minute ventilation recovery time

G Hernandez, R Fernandez, E Luzon, R Cuena… - Chest, 2007 - Elsevier
… The recovery time needed to reduce V.e to half the difference between the V.e measured
at the end of a successful SBT and basal V.e (RT50%ΔV.e) was lower in patients who had …

[HTML][HTML] Polymorphisms in the Haem Oxygenase-1 promoter are not associated with severity of Plasmodium falciparum malaria in Ghanaian children

HH Hansson, L Maretty, C Balle, BQ Goka, E Luzon… - Malaria Journal, 2015 - Springer
Background Haem oxygenase-1 (HO-1) catabolizes haem and has both cytotoxic and
cytoprotective effects. Polymorphisms in the promoter of the Haem oxygenase-1 (HMOX1) gene …

Eddy shedding from the Kuroshio bend at Luzon Strait

Y Jia, Q Liu - Journal of Oceanography, 2004 - Springer
… N, 121E south of Luzon Strait, deflects at about (21N, 118E) then flows out of the Luzon
Strait. … The area occupied by the Kuroshio bend is called the KB area (18.75–22N, 117.25–123E) …

[HTML][HTML] Vitamin E prevents lipid peroxidation and iron accumulation in PLA2G6-Associated Neurodegeneration

I Villalón-García, M Álvarez-Córdoba… - Neurobiology of …, 2022 - Elsevier
… All these pathological features were reverted with vitamin E treatment. … The main pathological
alterations were corrected by Vitamin E supplementation in both models, suggesting that …