Rationale: Cystic fibrosis (CF) is an autosomal recessive disease characterized by abnormal
airways secretions, chronic endobronchial infection, and progressive airway obstruction. …

There is renewed interest in non–cystic fibrosis bronchiectasis, which is a cause of significant
morbidity in adults and can be diagnosed by high-resolution chest computed tomography …

Importance In asthma and other diseases, vitamin D insufficiency is associated with adverse
outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D 3 …

Description: The Cystic Fibrosis (CF) Foundation developed clinical care guidelines for the
prevention of Pseudomonas aeruginosa infection, the treatment of initial P. aeruginosa …

BACKGROUND Hospitalized patients frequently misuse their respiratory inhalers, yet it is
unclear what the most effective hospital-based educational intervention is for this population. …

The epigenome provides a substrate through which environmental exposures can exert
their effects on gene expression and disease risk, but the relative importance of epigenetic …

Background Acute exacerbations of COPD (AE-COPD) are a leading cause of hospitalizations
in the United States. To estimate the burden of disease (eg, prevalence and cost), identify …

Background The lung has a diverse microbiome that is modest in biomass. This microbiome
differs in asthmatic patients compared with control subjects, but the effects of clinical …

To assess the ability of the nose to warm and humidify inhaled air, we developed a nasopharyngeal
probe and measured the temperature and humidity of air exiting the nasal cavity. We …

Background The relationship between asthma, atopy, and underlying type 2 (T2) airway
inflammation is complex. Although the bacterial airway microbiota is known to differ in asthmatic …