Animal models of acute lung injury
G Matute-Bello, CW Frevert… - American Journal of …, 2008 - journals.physiology.org
Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis,
injury of the alveolar epithelium and endothelium, hyaline membrane formation, and …
injury of the alveolar epithelium and endothelium, hyaline membrane formation, and …
The role of apoptosis in acute lung injury
TR Martin, M Nakamura, G Matute-Bello - Critical care medicine, 2003 - journals.lww.com
… Other constituents of the alveolar inflammatory milieu, such as granulocyte colony-stimulating
factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), modulate …
factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), modulate …
Apoptosis and epithelial injury in the lungs
…, N Hagimoto, M Nakamura, G Matute-Bello - Proceedings of the …, 2005 - atsjournals.org
… The studies by Matute-Bello and colleagues and by Albertine and coworkers suggested
that activation of the Fas pathway is an important mechanism of alveolar epithelial injury in the …
that activation of the Fas pathway is an important mechanism of alveolar epithelial injury in the …
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals
G Matute-Bello, G Downey, BB Moore… - American journal of …, 2011 - atsjournals.org
Acute lung injury (ALI) is well defined in humans, but there is no agreement as to the main
features of acute lung injury in animal models. A Committee was organized to determine the …
features of acute lung injury in animal models. A Committee was organized to determine the …
Neutrophil apoptosis in the acute respiratory distress syndrome
G Matute-Bello, WC Liles, F RADELLA… - American journal of …, 1997 - atsjournals.org
… we immunodepleted BAL fluid of each of the following cytokines: G-CSF, GM-CSF, IL-6, and
IFN-γ. Neutralizing polyclonal antibodies directed against human G-CSF, GM-CSF, IL-6 and …
IFN-γ. Neutralizing polyclonal antibodies directed against human G-CSF, GM-CSF, IL-6 and …
Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS)
G Matute-Bello, WC Liles, KP Steinberg… - The Journal of …, 1999 - journals.aai.org
The goals of this study were to determine whether the Fas-dependent apoptosis pathway is
active in the lungs of patients with the acute respiratory distress syndrome (ARDS), and …
active in the lungs of patients with the acute respiratory distress syndrome (ARDS), and …
Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report
…, M Witzenrath, RL Zemans, G Matute-Bello - American journal of …, 2022 - atsjournals.org
Advancements in methods, technology, and our understanding of the pathobiology of lung
injury have created the need to update the definition of experimental acute lung injury (ALI). …
injury have created the need to update the definition of experimental acute lung injury (ALI). …
Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation
G Matute-Bello, RK Winn, M Jonas, EY Chi… - The American journal of …, 2001 - Elsevier
Activation of the Fas/FasL system induces apoptosis of susceptible cells, but may also lead
to nuclear factor κB activation. Our goal was to determine whether local Fas activation …
to nuclear factor κB activation. Our goal was to determine whether local Fas activation …
Airway epithelial regulation of pulmonary immune homeostasis and inflammation
…, TL Hackett, WA Altemeier, G Matute-Bello… - Clinical …, 2014 - Elsevier
Recent genetic, structural and functional studies have identified the airway and lung epithelium
as a key orchestrator of the immune response. Further, there is now strong evidence that …
as a key orchestrator of the immune response. Further, there is now strong evidence that …
Augmented lung injury due to interaction between hyperoxia and mechanical ventilation
SE Sinclair, WA Altemeier, G Matute-Bello… - Critical care …, 2004 - journals.lww.com
Objective: Mechanical overdistension and hyperoxia can independently cause lung injury,
yet little is known about their combined effects. We hypothesized that hyperoxia exacerbates …
yet little is known about their combined effects. We hypothesized that hyperoxia exacerbates …