User profiles for George Cheng

George Zhi Cheng MD PhD

UCSD Health
Verified email at health.ucsd.edu
Cited by 4273

The mechanics of running: how does stiffness couple with speed?

TA McMahon, GC Cheng - Journal of biomechanics, 1990 - Elsevier
A mathematical model for terrestrial running is presented, based on a leg with the properties
of a simple spring. Experimental force-platform evidence is reviewed justifying the …

Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation.

GC Cheng, HM Loree, RD Kamm, MC Fishbein… - Circulation, 1993 - Am Heart Assoc
BACKGROUND Although rupture of an atherosclerotic plaque is considered to be the cause
of most acute coronary syndromes, the mechanism of plaque rupture is controversial. …

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

GZ Cheng, J Chan, Q Wang, W Zhang, CD Sun… - Cancer research, 2007 - AACR
Metastasis, the cardinal feature of malignant tumors, is an important clinical variable in patient
prognosis. To understand the basis for metastasis, we systematically selected for highly …

The Akt/PKB pathway: molecular target for cancer drug discovery

JQ Cheng, CW Lindsley, GZ Cheng, H Yang… - Oncogene, 2005 - nature.com
The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

[BOOK][B] Instrument engineers' handbook, volume two: Process control and optimization

…, J Madar, J Abonyi, RR Rhinehart, GS Cheng… - 2018 - taylorfrancis.com
The latest update to Bela Liptak's acclaimed "bible" of instrument engineering is now available.
Retaining the format that made the previous editions bestsellers in their own right, the …

[HTML][HTML] Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function

GZ Cheng, WZ Zhang, M Sun, Q Wang… - Journal of biological …, 2008 - ASBMB
To explore the basis of metastasis, we compared the human breast cancer lines MCF-7 and
MDA-MB453, which have low invasive ability, with their sublines MCF7-I4 and MDA-MB453-…

Character controllers using motion vaes

HY Ling, F Zinno, G Cheng… - ACM Transactions on …, 2020 - dl.acm.org
A fundamental problem in computer animation is that of realizing purposeful and realistic
human movement given a sufficiently-rich set of motion capture clips. We learn data-driven …

The flow of gases in pipes at low pressures

GP Brown, A DiNardo, GK Cheng… - Journal of Applied …, 1946 - pubs.aip.org
Data are presented on the flow of air at low pressures in copper pipes of radius 0.795 and
1.30 cm; iron pipes of radius 2.64, 5.12, and 10.1 cm; and for hydrogen in a copper pipe of …

Engineering a highly elastic human protein–based sealant for surgical applications

…, YN Zhang, A Assmann, ES Sani, G Cheng… - Science translational …, 2017 - science.org
Surgical sealants have been used for sealing or reconnecting ruptured tissues but often
have low adhesion, inappropriate mechanical strength, cytotoxicity concerns, and poor …

A highly adhesive and naturally derived sealant

…, A Vegh, M Ghasemi-Rad, S Bagherifard, G Cheng… - Biomaterials, 2017 - Elsevier
Conventional surgical techniques to seal and repair defects in highly stressed elastic tissues
are insufficient. Therefore, this study aimed to engineer an inexpensive, highly adhesive, …