Background The proliferation of inhaler devices has resulted in a confusing number of
choices for clinicians who are selecting a delivery device for aerosol therapy. There are …

Objective: The purpose of this study was to determine whether aerosolized antibiotics,
which achieve high drug concentrations in the target organ, would more effectively treat …

… Correspondence and requests for reprints should be addressed to Gerald C. Smaldone,
Pulmonary and Critical Care Medicine, T17, 040 Health Science Center, State University of New …

Background Conventional regimens of immunosuppressive drugs often do not prevent
chronic rejection after lung transplantation. Topical delivery of cyclosporine in addition to …

National and international guidelines recommend droplet/airborne transmission and contact
precautions for those caring for coronavirus disease 2019 (COVID-19) patients in …

Rationale: Multidrug-resistant organisms (MDRO) are the dominant airway pathogens in the
intensive care unit (ICU) and present a major treatment challenge to intensivists. …

… The response was assessed by a) changes in the volume of respiratory secretions; b)
effect on bacterial cultures; and c) changes in the inflammatory cells and mediators of …

The elderly have an increased incidence of oropharyngeal colonization with respiratory
pathogens, a well-known risk factor for the development of pneumonia. Changes in the oral …

… 3 Correspondence and requests for reprints should be addressed to Gerald C. Smaldone,
MD, Ph.D., Pulmonary Disease Division, State University of New York at Stony Brook, HSC Tl7…

In cystic fibrosis (CF), the clinical effectiveness of aerosolized antibiotics is controversial.
Previous investigators have not considered the type of nebulizer, droplet size, and dose to the …