Use of adjunctive aerosolized antimicrobial therapy in the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii ventilator-associated pneumonia
HM Arnold, AM Sawyer, MH Kollef - Respiratory care, 2012 - rc.rcjournal.com
BACKGROUND: Adjunctive aerosolized antibiotics (AAA) have been recommended in the
setting of Gram-negative ventilator-associated pneumonia (VAP), but little is known about …
setting of Gram-negative ventilator-associated pneumonia (VAP), but little is known about …
[HTML][HTML] Adjunctive aerosolized colistin for multi-drug resistant gram-negative pneumonia in the critically ill: a retrospective study
…, EN Frazee, HA Personett, GE Schramm, HM Arnold… - BMC …, 2013 - Springer
Background The incidence of multi-drug resistant (MDR) gram-negative (GN) organisms
including Pseudomonas and Acinetobacter spp has increased in the last decade, prompting re-…
including Pseudomonas and Acinetobacter spp has increased in the last decade, prompting re-…
Hospital resource utilization and costs of inappropriate treatment of candidemia
HM Arnold, ST Micek, AF Shorr… - … : The Journal of …, 2010 - Wiley Online Library
Study Objectives. To evaluate the impact of inappropriate therapy—defined as delayed
antifungal therapy beyond 24 hours from culture collection, inadequate antifungal dosage, or …
antifungal therapy beyond 24 hours from culture collection, inadequate antifungal dosage, or …
Antibiotic stewardship in the intensive care unit
HM Arnold, ST Micek, LP Skrupky… - Seminars in respiratory …, 2011 - thieme-connect.com
Antimicrobial stewardship encompasses the optimization of agent selection, dose, and
duration leading to the best clinical outcome in the treatment or prevention of infection. Ideally, …
duration leading to the best clinical outcome in the treatment or prevention of infection. Ideally, …
Prolonged infusion antibiotics for suspected gram-negative infections in the ICU: a before-after study
HM Arnold, JM Hollands, LP Skrupky… - Annals of …, 2013 - journals.sagepub.com
BACKGROUND: β-Lactam antibiotics demonstrate time-dependent killing. Prolonged infusion
of these agents is commonly performed to optimize the time the unbound concentration of …
of these agents is commonly performed to optimize the time the unbound concentration of …
Occurrence and predictors of dexmedetomidine infusion intolerance and failure
BR Tellor, HM Arnold, ST Micek, MH Kollef - Hospital practice, 2012 - Taylor & Francis
Background: Dexmedetomidine, a selective α 2 adrenergic receptor agonist, exhibits sedative,
analgesic, anxiolytic, and sympatholytic effects, and may aid in controlling agitation in the …
analgesic, anxiolytic, and sympatholytic effects, and may aid in controlling agitation in the …
Optimizing sustained use of sedation in mechanically ventilated patients: focus on safety
HM Arnold, JM Hollands, LP Skrupky… - Current Drug …, 2010 - ingentaconnect.com
Optimizing sustained use of ICU sedation in mechanically ventilated patients requires
careful consideration of drug-specific characteristics (EG pharmacokinetics), consideration of …
careful consideration of drug-specific characteristics (EG pharmacokinetics), consideration of …
Assessment of an Alternative Meropenem Dosing Strategy Compared with Imipenem‐Cilastatin or Traditional Meropenem Dosing After Cefepime Failure or …
HM Arnold, PS McKinnon, KM Augustin… - … : The Journal of …, 2009 - Wiley Online Library
Study Objective. To compare clinical outcomes of patients receiving an alternative dosage of
meropenem with those of patients receiving imipenem‐cilastatin or the traditional dosage of …
meropenem with those of patients receiving imipenem‐cilastatin or the traditional dosage of …
[HTML][HTML] Assessment of imipenem-cilastatin 500mg q6h, meropenem 1g q8h and meropenem 500mg q6h following cefepime use in adult patients with neutropenic …
HM Arnold, PS McKinnon, KM Augustin… - …, 2009 - ncbi.nlm.nih.gov
Study objective An alternative meropenem dosing strategy (500mg q6h) has been postulated
to provide similar pharmacodynamics based on% T> MIC as traditional dosing with 1gm …
to provide similar pharmacodynamics based on% T> MIC as traditional dosing with 1gm …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, H Alavere, MTS Alibrandi, P Almgren, AM Arnold… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …