Crizotinib is the standard of care for advanced non–small cell lung cancer (NSCLC) patients
harboring the anaplastic lymphoma kinase (ALK) fusion gene, but resistance invariably …

OBJECTIVE: We examined the prognosis of patients with leptomeningeal metastasis (LM)
from non-small cell lung cancer (NSCLC) and that stratified by epidermal growth factor …

Tumors are presumed to contain a small population of cancer stem cells ( CSC s) that initiate
tumor growth and promote tumor spreading. Multidrug resistance in CSC s is thought to …

The standard CHOP therapy for peripheral T-cell lymphoma has resulted in unsatisfactory
outcomes and it is still not clear what is the optimal front-line therapy. We conducted a …

Introduction: Programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1)
play a major role in suppressing the immune system during the formation of the PD-1/PD-…

A solitary Peutz-Jeghers-type hamartomatous polyp in the duodenum is rare, and few reports
have described its characteristic endoscopic features. We describe three cases of solitary …

Purpose Although there are several reports concerning gemcitabine-induced interstitial lung
disease (ILD), the risk factors for ILD are not well known. In addition, data comparing the …

We describe an 87-year-old woman with a large ileal gastrointestinal stromal tumor (GIST)
causing hemoperitoneum. A CT scan demonstrated a large heterogeneous mass measuring …

Loss of expression of HLA class I antigens has been demonstrated in a wide variety of tumors
and is considered to be one of the mechanisms whereby tumors escape T-cell surveillance…

Primary effusion lymphoma (PEL) is a newly described high-grade B cell lymphoma
developing in association with human herpes virus type 8 (HHV-8) in human immunodeficiency …