Deep inflation of the lung stimulates surfactant secretion by unknown mechanisms. The
hypothesis that mechanical distension directly stimulates type II cells to secrete surfactant was …

Background Pirfenidone has been shown to slow disease progression in patients with
idiopathic pulmonary fibrosis (IPF). However, there are few treatment options for progressive …

The lung is a dynamic organ that is subjected to mechanical forces throughout development
and adult life. This review article addresses the types of mechanical forces in the lung and …

After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF)
in 2011, we investigated clinical management practices for patients with IPF according to …

Background: A high flow of air applied by large bore nasal cannulae has been suggested to
improve symptoms of chronic respiratory insufficiency. In pediatric patients, nasal high-flow (…

Objective There is a paucity of observational data on antifibrotic therapy for idiopathic pulmonary
fibrosis (IPF). We aimed to assess the course of disease of IPF patients with and without …

The term idiopathic pulmonary arterial hypertension (IPAH) is used to categorize patients with
pre-capillary pulmonary hypertension of unknown origin. There is considerable variability …

Differences in cytokine patterns in stable chronic obstructive pulmonary disease (COPD),
exacerbated COPD, smokers without apparent COPD, and healthy volunteers should be of …

Background Much progress has been made in the treatment of lung cancer in the last ten
years (adjuvant chemotherapy, targeted therapy, individualized therapy). Nonetheless, lung …

Background The INSIGHTS-IPF registry provides one of the largest data sets of clinical data
and self-reported patient related outcomes including health related quality of life (QoL) on …