Outcomes of anticancer therapy vary dramatically among patients due to diverse genetic
and molecular backgrounds, highlighting extensive intertumoral heterogeneity. The …

Background Recently, the discovery of copy number variation (CNV) led researchers to think
that there are more variations of genomic DNA than initially believed. Moreover, a certain …

Accurate detection of genomic alterations using high-throughput sequencing is an essential
component of precision cancer medicine. We characterize the variant allele fractions (VAFs) …

The method for genome-wide association study (GWAS) based on copy number variation (CNV)
is not as well established as that for single nucleotide polymorphism (SNP)–GWAS. …

Background Aberrant gene expression in the gut mucosa might contribute to the initiation
and progression of Crohn's disease (CD). RNA sequencing (RNA-seq) provides precise …

Purpose: Tumors continuously evolve to maintain growth; secondary mutations facilitate this
process, resulting in high tumor heterogeneity. In this study, we compared mutations in …

Background Marbling score (MS) is the major quantitative trait that affects carcass quality in
beef cattle. In this study, we examined the association between genetic polymorphisms of the …

Aspirin-exacerbated respiratory disease (AERD) is a nonallergic clinical syndrome characterized
by a severe decline in forced expiratory volume in one second (FEV1) following the …

Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones
could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has …

Aspirin-intolerant asthma (AIA) is a rare condition that is characterized by the development
of bronchoconstriction in asthmatic patients after ingestion of non-steroidal anti-inflammatory …