[HTML][HTML] Hydrocortisone plus fludrocortisone for adults with septic shock

…, F Baudin, A Combes, J Bohé… - … England Journal of …, 2018 - Mass Medical Soc
Background Septic shock is characterized by dysregulation of the host response to infection,
with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with …

Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose‐response study

J Bohé, A Low, RR Wolfe… - The Journal of physiology, 2003 - Wiley Online Library
To test the hypothesis that muscle protein synthesis (MPS) is regulated by the concentration
of extracellular amino acids, we investigated the dose‐response relationship between the …

Rapid report: latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids

J Bohé, JFA Low, RR Wolfe… - The Journal of …, 2001 - Wiley Online Library
1 The aim of this study was to describe the time course of the response of human muscle
protein synthesis (MPS) to a square wave increase in availability of amino acids (AAs) in …

Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock

G Monneret, A Lepape, N Voirin, J Bohé, F Venet… - Intensive care …, 2006 - Springer
Objective The immediate overwhelming release of inflammatory mediators in septic shock is
rapidly followed by strong anti-inflammatory responses inducing a state of …

[HTML][HTML] Timing of renal-replacement therapy in patients with acute kidney injury and sepsis

…, F Montini, R Bruyère, C Lebert, J Bohé… - … England Journal of …, 2018 - Mass Medical Soc
Background Acute kidney injury is the most frequent complication in patients with septic
shock and is an independent risk factor for death. Although renal-replacement therapy is the …

Increased circulating regulatory T cells (CD4+CD25+CD127) contribute to lymphocyte anergy in septic shock patients

…, A Geeraert, C Malcus, F Poitevin, J Bohé… - Intensive care …, 2009 - Springer
Purpose Sepsis syndrome represents the leading cause of death in intensive care unit.
Patients present features consistent with a decline in immune responsiveness potentially …

Marked elevation of human circulating CD4+ CD25+ regulatory T cells in sepsis-induced immunoparalysis

G Monneret, AL Debard, F Venet, J Bohe… - Critical care …, 2003 - journals.lww.com
Objective Immunoparalysis has recently emerged as a possible cause explaining the failure
of clinical trials in septic shock. Because human peripheral blood CD4+ CD25+ T cells have …

Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised …

…, A Robine, M Beuzelin, J Badie, G Chevrel, J Bohe… - The Lancet, 2021 - thelancet.com
Background Delaying renal replacement therapy (RRT) for some time in critically ill patients
with severe acute kidney injury and no severe complication is safe and allows optimisation …

The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration

G Monneret, ME Finck, F Venet, AL Debard, J Bohé… - Immunology letters, 2004 - Elsevier
The diminished expression of HLA-DR on monocytes has been proposed as a reliable
marker of immunosuppression occuring during septic shock. The objective of the present …

Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock

…, A Lepape, N Voirin, E Tognet, F Venet, J Bohé… - Intensive care …, 2010 - Springer
Purpose Sepsis-induced immunosuppression is postulated to contribute to a heightened
risk of nosocomial infection (NI). This prospective, single-center, observational study was …