User profiles for Kalev Freeman

Kalev Freeman

Associate Professor of Surgery and Pharmacology, University of Vermont
Verified email at uvm.edu
Cited by 2076

Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains

I Lerman, BC Harrison, K Freeman… - Journal of applied …, 2002 - journals.physiology.org
The goal of this study was to characterize the genetic contribution to both forced and voluntary
exercise performance and to determine whether performance in these two paradigms is …

[HTML][HTML] Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

K Freeman, I Lerman, EG Kranias… - The Journal of …, 2001 - Am Soc Clin Investig
The medical treatment of chronic heart failure has undergone a dramatic transition in the
past decade. Short-term approaches for altering hemodynamics have given way to long-term, …

Requirements and definitions in conflict of interest policies of medical journals

JA Blum, K Freeman, RC Dart, RJ Cooper - Jama, 2009 - jamanetwork.com
Context Conflicts of interest (COIs) may influence medical literature. However, it is unclear
whether medical journals have consistent policies for defining and soliciting COI disclosures. …

Clinical decisionmaking: opening the black box of cognitive reasoning

H Sandhu, C Carpenter, K Freeman, SG Nabors… - Annals of emergency …, 2006 - Elsevier
Henry David Thoreau said,“If one advances confidently in the direction of his dreams, and
endeavors to live the life he has imagined, he will meet with a success unexpected in common …

Traumatic brain injury causes endothelial dysfunction in the systemic microcirculation through arginase-1–dependent uncoupling of endothelial nitric oxide synthase

…, MT Nelson, GC Wellman, K Freeman - Journal of …, 2017 - liebertpub.com
Endothelial dysfunction is a hallmark of many chronic diseases, including diabetes and long-term
hypertension. We show that acute traumatic brain injury (TBI) leads to endothelial …

[HTML][HTML] Cognitive improvement after mild traumatic brain injury measured with functional neuroimaging during the acute period

GR Wylie, K Freeman, A Thomas, M Shpaner… - PloS one, 2015 - journals.plos.org
Functional neuroimaging studies in mild traumatic brain injury (mTBI) have been largely
limited to patients with persistent post-concussive symptoms, utilizing images obtained months …

Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function

…, MT Nelson, GC Wellman, K Freeman - Journal of the …, 2014 - Am Heart Assoc
Background Traumatic brain injury ( TBI ) has been reported to increase the concentration
of nitric oxide ( NO ) in the brain and can lead to loss of cerebrovascular tone; however, the …

Effects of presentation and electrocardiogram on time to treatment of hyperkalemia

K Freeman, JA Feldman, P Mitchell… - Academic …, 2008 - Wiley Online Library
Objectives: To assess the time to treatment for emergency department (ED) patients with
critical hyperkalemia and to determine whether the timing of treatment was associated with …

[HTML][HTML] Enhanced stability and oral bioavailability of cannabidiol in zein and whey protein composite nanoparticles by a modified anti-solvent approach

C Wang, J Wang, Y Sun, K Freeman, MA Mchenry… - Foods, 2022 - mdpi.com
Wide applications of cannabidiol (CBD) in the food and pharmaceutical industries are limited
due to its low bioavailability, sensitivity to environmental pressures and low water solubility. …

Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

…, MI Kotlikoff, MT Nelson, K Freeman - American Journal …, 2019 - journals.physiology.org
Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis
and release from neutrophils. Elevated circulating histones in trauma contribute to …