User profiles for Kelvin D MacDonald

Kelvin MacDonald

Oregon Health and Science University
Verified email at ohsu.edu
Cited by 954

Engineering lipid nanoparticles for enhanced intracellular delivery of mRNA through inhalation

…, Y Eygeris, E Bloom, X Tan, C Acosta, KD MacDonald… - ACS …, 2022 - ACS Publications
Despite lipid nanoparticles’ (LNPs) success in the effective and safe delivery of mRNA vaccines,
an inhalation-based mRNA therapy for lung diseases remains challenging. LNPs tend …

[HTML][HTML] Lipid nanoparticle-delivered chemically modified mRNA restores chloride secretion in cystic fibrosis

E Robinson, KD MacDonald, K Slaughter, M McKinney… - Molecular Therapy, 2018 - cell.com
The promise of gene therapy for the treatment of cystic fibrosis has yet to be fully clinically
realized despite years of effort toward correcting the underlying genetic defect in the cystic …

The effect of extended continuous positive airway pressure on changes in lung volumes in stable premature infants: a randomized controlled trial

…, KC Lund, RL Schelonka, KD MacDonald… - The Journal of …, 2020 - Elsevier
Objective To compare changes in lung volumes, as measured by functional residual
capacity (FRC), through to discharge in stable infants randomized to 2 weeks of extended …

Effect of vitamin C supplementation for pregnant smokers on offspring airway function and wheeze at age 5 years: follow-up of a randomized clinical trial

…, H Titus, KD MacDonald, D Gonzales… - JAMA …, 2023 - jamanetwork.com
Importance Vitamin C supplementation (500 mg/d) for pregnant smokers has been reported
to increase offspring airway function as measured by forced expiratory flow (FEF) through …

An improved simple method of mouse lung intubation

KD MacDonald, HYS Chang… - Journal of applied …, 2009 - journals.physiology.org
Given the ubiquitous use of mice to study lung disease, it is curious that more investigators
do not use repeated intubation to study mechanical and cellular changes in individual mice. …

Cystic Fibrosis Transmembrane Regulator Protein Mutations: 'Class' Opportunity for Novel Drug Innovation

KD MacDonald, KR McKenzie, PL Zeitlin - Pediatric drugs, 2007 - Springer
Cystic fibrosis (CF) is the most common autosomal, recessive, life-span shortening disease
in Caucasians. Since discovery of the gene for CF (cystic fibrosis transmembrane …

Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP4)

Y Norimatsu, AR Moran, KD MacDonald - Biochemical and biophysical …, 2012 - Elsevier
The goal of this study was to determine the mechanism of lubiprostone activation of
epithelial chloride transport. Lubiprostone is a bicyclic fatty acid approved for the treatment of …

Functional evaluation of the cystic fibrosis transmembrane conductance regulator in the endocervix

…, A Luo, S Wei, OD Slayden, KD Macdonald - Biology of …, 2022 - academic.oup.com
The cystic fibrosis transmembrane conductance regulator (CFTR) is an apical membrane
chloride/bicarbonate ion channel in epithelial cells. Mutations in CFTR cause cystic fibrosis, a …

Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis–based cell and mice models

A Mukherjee, KD MacDonald, J Kim, MI Henderson… - Science …, 2020 - science.org
Cystic fibrosis (CF) results from mutations in the chloride-conducting CF transmembrane
conductance regulator (CFTR) gene. Airway dehydration and impaired mucociliary clearance in …

Maternal high‐fat diet in mice leads to innate airway hyperresponsiveness in the adult offspring

KD MacDonald, AR Moran, AJ Scherman… - Physiological …, 2017 - Wiley Online Library
Maternal obesity prior to and during pregnancy has been associated with an increased
incidence of childhood asthma. As diets rich in saturated fat are linked to obesity and …